Efficiency analysis of clearance of two types of exogenous iron from the rat brain by Mössbauer spectroscopy

D. M. Polikarpov, V. M. Cherepanov, R. R. Gabbasov, M. A. Chuev, I. N. Mischenko, V. A. Korshunov, V. Y. Panchenko

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6 Citations (Scopus)

Abstract

Fe3O4 based ferrofluid was injected transcranially in the ventricle of the rat brain. At 3 months after the injection the rat was sacrificed and the brain was investigated by Mössbauer spectroscopy and histological Perls Prussian blue method. Joint analysis of histological and Mössbauer data confirms that superparamagnetic nanoparticles Fe3O4, which constituted about 91 % of the iron of the ferrofluid, were cleared from the brain, while the concomitant chemical compound containing ferric ion in the high-spin state, remains intact.

Original languageEnglish
Pages (from-to)83-88
Number of pages6
JournalHyperfine Interactions
Volume218
Issue number1-3
DOIs
Publication statusPublished - 2013
Externally publishedYes

Keywords

  • brain
  • magnetic nanoparticles
  • Mössbauer spectroscopy

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    Polikarpov, D. M., Cherepanov, V. M., Gabbasov, R. R., Chuev, M. A., Mischenko, I. N., Korshunov, V. A., & Panchenko, V. Y. (2013). Efficiency analysis of clearance of two types of exogenous iron from the rat brain by Mössbauer spectroscopy. Hyperfine Interactions, 218(1-3), 83-88. https://doi.org/10.1007/s10751-012-0713-5