Efficiency analysis of clearance of two types of exogenous iron from the rat brain by Mössbauer spectroscopy

D. M. Polikarpov; V. M. Cherepanov; R. R. Gabbasov; M. A. Chuev; I. N. Mischenko; V. A. Korshunov; V. Y. Panchenko

doi:10.1007/s10751-012-0713-5

Efficiency analysis of clearance of two types of exogenous iron from the rat brain by Mössbauer spectroscopy

D. M. Polikarpov, V. M. Cherepanov, R. R. Gabbasov, M. A. Chuev, I. N. Mischenko, V. A. Korshunov, V. Y. Panchenko

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Fe₃O₄ based ferrofluid was injected transcranially in the ventricle of the rat brain. At 3 months after the injection the rat was sacrificed and the brain was investigated by Mössbauer spectroscopy and histological Perls Prussian blue method. Joint analysis of histological and Mössbauer data confirms that superparamagnetic nanoparticles Fe₃O₄, which constituted about 91 % of the iron of the ferrofluid, were cleared from the brain, while the concomitant chemical compound containing ferric ion in the high-spin state, remains intact.

Original language	English
Pages (from-to)	83-88
Number of pages	6
Journal	Hyperfine Interactions
Volume	218
Issue number	1-3
DOIs	https://doi.org/10.1007/s10751-012-0713-5
Publication status	Published - 2013
Externally published	Yes

Keywords

brain
magnetic nanoparticles
Mössbauer spectroscopy

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10.1007/s10751-012-0713-5

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title = "Efficiency analysis of clearance of two types of exogenous iron from the rat brain by M{\"o}ssbauer spectroscopy",

abstract = "Fe3O4 based ferrofluid was injected transcranially in the ventricle of the rat brain. At 3 months after the injection the rat was sacrificed and the brain was investigated by M{\"o}ssbauer spectroscopy and histological Perls Prussian blue method. Joint analysis of histological and M{\"o}ssbauer data confirms that superparamagnetic nanoparticles Fe3O4, which constituted about 91 % of the iron of the ferrofluid, were cleared from the brain, while the concomitant chemical compound containing ferric ion in the high-spin state, remains intact.",

keywords = "brain, magnetic nanoparticles, M{\"o}ssbauer spectroscopy",

author = "Polikarpov, {D. M.} and Cherepanov, {V. M.} and Gabbasov, {R. R.} and Chuev, {M. A.} and Mischenko, {I. N.} and Korshunov, {V. A.} and Panchenko, {V. Y.}",

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doi = "10.1007/s10751-012-0713-5",

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AU - Polikarpov, D. M.

AU - Cherepanov, V. M.

AU - Gabbasov, R. R.

AU - Chuev, M. A.

AU - Mischenko, I. N.

AU - Korshunov, V. A.

AU - Panchenko, V. Y.

PY - 2013

Y1 - 2013

N2 - Fe3O4 based ferrofluid was injected transcranially in the ventricle of the rat brain. At 3 months after the injection the rat was sacrificed and the brain was investigated by Mössbauer spectroscopy and histological Perls Prussian blue method. Joint analysis of histological and Mössbauer data confirms that superparamagnetic nanoparticles Fe3O4, which constituted about 91 % of the iron of the ferrofluid, were cleared from the brain, while the concomitant chemical compound containing ferric ion in the high-spin state, remains intact.

AB - Fe3O4 based ferrofluid was injected transcranially in the ventricle of the rat brain. At 3 months after the injection the rat was sacrificed and the brain was investigated by Mössbauer spectroscopy and histological Perls Prussian blue method. Joint analysis of histological and Mössbauer data confirms that superparamagnetic nanoparticles Fe3O4, which constituted about 91 % of the iron of the ferrofluid, were cleared from the brain, while the concomitant chemical compound containing ferric ion in the high-spin state, remains intact.

KW - brain

KW - magnetic nanoparticles

KW - Mössbauer spectroscopy

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SN - 0304-3843

VL - 218

SP - 83

EP - 88

JO - Hyperfine Interactions

JF - Hyperfine Interactions

IS - 1-3

ER -

Efficiency analysis of clearance of two types of exogenous iron from the rat brain by Mössbauer spectroscopy

Abstract

Keywords

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