Egocentric versus allocentric spatial memory in behavioral variant frontotemporal dementia and Alzheimer's disease

Sicong Tu, Hugo J. Spiers, John R. Hodges, Olivier Piguet, Michael Hornberger*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    48 Citations (Scopus)

    Abstract

    Background: Diagnosis of behavioral variant frontotemporal dementia (bvFTD) can be challenging, in particular when patients present with significant memory problems, which can increase the chance of a misdiagnosis of Alzheimer's disease (AD). Growing evidence suggests spatial orientation is a reliable cognitive marker able to differentiate these two clinical syndromes. Objective: Assess the integrity of egocentric and allocentric heading orientation and memory in bvFTD and AD, and their clinical implications. Method: A cohort of 22 patients with dementia (11 bvFTD; 11 AD) and 14 healthy controls were assessed on the virtual supermarket task of spatial orientation and a battery of standardized neuropsychological measures of visual and verbal memory performance. Results: Judgements of egocentric and allocentric heading direction were differentially impaired in bvFTD and AD, with AD performing significantly worse on egocentric heading judgements than bvFTD. Both patient cohorts, however, showed similar degree of impaired allocentric spatial representation, and associated hippocampal pathology. Conclusions: The findings suggest egocentric heading judgements offer a more sensitive discriminant of bvFTD and AD than allocentric map-based measures of spatial memory.

    Original languageEnglish
    Pages (from-to)883-892
    Number of pages10
    JournalJournal of Alzheimer's Disease
    Volume59
    Issue number3
    DOIs
    Publication statusPublished - 2017

    Keywords

    • Alzheimer's disease
    • frontotemporal dementia
    • hippocampus
    • orientation

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