TY - GEN
T1 - Electrically evoked potentials in an ovine model for the evaluation of visual prosthesis efficacy
AU - Barriga-Rivera, Alejandro
AU - Eiber, Calvin D.
AU - Dodds, Christopher W. D.
AU - Fung, Adrian T.
AU - Tatarinoff, Veronica
AU - Lovell, Nigel H.
AU - Suaning, Gregg J.
PY - 2015
Y1 - 2015
N2 - Visual prostheses are becoming a reality as a therapy to restore functional vision to the blind. New stimulation strategies and novel electrode designs are contributing to accelerate the development of such devices triggering the interest of scientists, clinicians and the blind community worldwide. In this scenario, there is a need for large animal models that are suitable for preclinical testing of retinal neuroprostheses. This study presents an electrophysiology assessment of an ovine model for single and simultaneous electrode stimulation from the suprachoroidal space, using symmetric biphasic current pulses with a monopolar return configuration. Visually and electrically evoked potentials were recorded using supradural surface electrodes, showing charge thresholds comparable to those in humans. This model represents an alternative to feline or canine models with analogous activation levels and an eye anatomy similar to that of humans.
AB - Visual prostheses are becoming a reality as a therapy to restore functional vision to the blind. New stimulation strategies and novel electrode designs are contributing to accelerate the development of such devices triggering the interest of scientists, clinicians and the blind community worldwide. In this scenario, there is a need for large animal models that are suitable for preclinical testing of retinal neuroprostheses. This study presents an electrophysiology assessment of an ovine model for single and simultaneous electrode stimulation from the suprachoroidal space, using symmetric biphasic current pulses with a monopolar return configuration. Visually and electrically evoked potentials were recorded using supradural surface electrodes, showing charge thresholds comparable to those in humans. This model represents an alternative to feline or canine models with analogous activation levels and an eye anatomy similar to that of humans.
UR - http://www.scopus.com/inward/record.url?scp=84953214394&partnerID=8YFLogxK
U2 - 10.1109/EMBC.2015.7319112
DO - 10.1109/EMBC.2015.7319112
M3 - Conference proceeding contribution
C2 - 26737012
SN - 9781424492701
T3 - IEEE Engineering in Medicine and Biology Society Conference Proceedings
SP - 3359
EP - 3362
BT - 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
PB - Institute of Electrical and Electronics Engineers (IEEE)
CY - Piscataway, NJ
T2 - 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Y2 - 25 August 2015 through 29 August 2015
ER -