Electrically evoked potentials in an ovine model for the evaluation of visual prosthesis efficacy

Alejandro Barriga-Rivera*, Calvin D. Eiber, Christopher W. D. Dodds, Adrian T. Fung, Veronica Tatarinoff, Nigel H. Lovell, Gregg J. Suaning

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review

4 Citations (Scopus)

Abstract

Visual prostheses are becoming a reality as a therapy to restore functional vision to the blind. New stimulation strategies and novel electrode designs are contributing to accelerate the development of such devices triggering the interest of scientists, clinicians and the blind community worldwide. In this scenario, there is a need for large animal models that are suitable for preclinical testing of retinal neuroprostheses. This study presents an electrophysiology assessment of an ovine model for single and simultaneous electrode stimulation from the suprachoroidal space, using symmetric biphasic current pulses with a monopolar return configuration. Visually and electrically evoked potentials were recorded using supradural surface electrodes, showing charge thresholds comparable to those in humans. This model represents an alternative to feline or canine models with analogous activation levels and an eye anatomy similar to that of humans.

Original languageEnglish
Title of host publication2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
Place of PublicationPiscataway, NJ
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Pages3359-3362
Number of pages4
ISBN (Electronic)9781424492718
ISBN (Print)9781424492701
DOIs
Publication statusPublished - 2015
Externally publishedYes
Event37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) - Milan, Italy
Duration: 25 Aug 201529 Aug 2015

Publication series

NameIEEE Engineering in Medicine and Biology Society Conference Proceedings
PublisherIEEE
ISSN (Print)1557-170X

Conference

Conference37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
CountryItaly
CityMilan
Period25/08/1529/08/15

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