Electroactive and biocompatible hydroxyl- functionalized graphene by ball milling

Lu Yan, Mimi Lin, Chao Zeng, Zhi Chen, Shu Zhang, Xinmei Zhao, Aiguo Wu, Yaping Wang, Liming Dai, Jia Qu*, Mingming Guo, Yong Liu

*Corresponding author for this work

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Hydroxyl-functionalized graphene (G-OH) was efficiently produced from exfoliation of graphite powder by ball milling the presence of potassium hydroxide (KOH). While the nanoscale graphene sheets were confirmed by various characterization techniques, including atomic force microscopy (AFM), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and UV-vis spectroscopy, the formation of hydroxyl groups in G-OH was revealed by Fourier transform infrared (FTIR), Nuclear Magnetic Resonance analysis (NMR), Raman and X-ray photoelectron spectroscopic (XPS) measurements. The as-prepared G-OH showed strong hydrophilicity with good solubility in water, excellent electrochemical activity and no influence on the growth of human retinal pigment epithelium (RPE) cells. More than 80% cell survival rate and less than 7% lactate dehydrogenase (LDH) release were observed for RPE cells treated with G-OH, indicating excellent biocompatibility.

Original languageEnglish
Pages (from-to)8367-8371
Number of pages5
JournalJournal of Materials Chemistry
Volume22
Issue number17
DOIs
Publication statusPublished - 7 May 2012

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    Yan, L., Lin, M., Zeng, C., Chen, Z., Zhang, S., Zhao, X., ... Liu, Y. (2012). Electroactive and biocompatible hydroxyl- functionalized graphene by ball milling. Journal of Materials Chemistry, 22(17), 8367-8371. https://doi.org/10.1039/c2jm30961k