Electrochemical determination of the anticancer herbal drug shikonin at a nanostructured poly(hydroxymethylated-3,4-ethylenedioxythiophene) modified electrode

Liping Wu, Limin Lu, Long Zhang, Jingkun Xu*, Kaixin Zhang, Yangping Wen, Xuemin Duan, Fan Yang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

A simple and sensitive method is described for the electrochemical determination of shikonin, a widely used anti-tumoral agent, based on its electrochemical oxidation at a nanostructured poly(hydroxymethylated-3,4-ethylenedioxy-thiophene) (PEDOT-MeOH) electrode, which was fabricated by a facile electropolymerization method. Compared with bare and poly(3,4-ethylenedioxythiophene) (PEDOT) electrodes, the PEDOT-MeOH film exhibited a distinctly higher activity for the electrooxidation of shikonin. The PEDOT-MeOH electrode showed a wide linear response for shikonin in the concentration range from 1.0nM to 10.0μM with detection limit of 0.3nM. Furthermore, the PEDOT-MeOH electrode displayed high stability, good reproducibility and high sensitivity for the detection of shikonin.

Original languageEnglish
Pages (from-to)2244-2250
Number of pages7
JournalElectroanalysis
Volume25
Issue number9
DOIs
Publication statusPublished - Sep 2013
Externally publishedYes

Keywords

  • PEDOT-MeOH
  • electropolymerization
  • shikonin
  • modified electrode
  • electrochemical determination

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