Electrochemical determination of the anticancer herbal drug shikonin at a nanostructured poly(hydroxymethylated-3,4-ethylenedioxythiophene) modified electrode

Liping Wu; Limin Lu; Long Zhang; Jingkun Xu; Kaixin Zhang; Yangping Wen; Xuemin Duan; Fan Yang

doi:10.1002/elan.201300247

Electrochemical determination of the anticancer herbal drug shikonin at a nanostructured poly(hydroxymethylated-3,4-ethylenedioxythiophene) modified electrode

Liping Wu, Limin Lu, Long Zhang, Jingkun Xu^*, Kaixin Zhang, Yangping Wen, Xuemin Duan, Fan Yang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

A simple and sensitive method is described for the electrochemical determination of shikonin, a widely used anti-tumoral agent, based on its electrochemical oxidation at a nanostructured poly(hydroxymethylated-3,4-ethylenedioxy-thiophene) (PEDOT-MeOH) electrode, which was fabricated by a facile electropolymerization method. Compared with bare and poly(3,4-ethylenedioxythiophene) (PEDOT) electrodes, the PEDOT-MeOH film exhibited a distinctly higher activity for the electrooxidation of shikonin. The PEDOT-MeOH electrode showed a wide linear response for shikonin in the concentration range from 1.0nM to 10.0μM with detection limit of 0.3nM. Furthermore, the PEDOT-MeOH electrode displayed high stability, good reproducibility and high sensitivity for the detection of shikonin.

Original language	English
Pages (from-to)	2244-2250
Number of pages	7
Journal	Electroanalysis
Volume	25
Issue number	9
DOIs	https://doi.org/10.1002/elan.201300247
Publication status	Published - Sep 2013
Externally published	Yes

Keywords

PEDOT-MeOH
electropolymerization
shikonin
modified electrode
electrochemical determination

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10.1002/elan.201300247

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title = "Electrochemical determination of the anticancer herbal drug shikonin at a nanostructured poly(hydroxymethylated-3,4-ethylenedioxythiophene) modified electrode",

abstract = "A simple and sensitive method is described for the electrochemical determination of shikonin, a widely used anti-tumoral agent, based on its electrochemical oxidation at a nanostructured poly(hydroxymethylated-3,4-ethylenedioxy-thiophene) (PEDOT-MeOH) electrode, which was fabricated by a facile electropolymerization method. Compared with bare and poly(3,4-ethylenedioxythiophene) (PEDOT) electrodes, the PEDOT-MeOH film exhibited a distinctly higher activity for the electrooxidation of shikonin. The PEDOT-MeOH electrode showed a wide linear response for shikonin in the concentration range from 1.0nM to 10.0μM with detection limit of 0.3nM. Furthermore, the PEDOT-MeOH electrode displayed high stability, good reproducibility and high sensitivity for the detection of shikonin.",

keywords = "PEDOT-MeOH, electropolymerization, shikonin, modified electrode, electrochemical determination",

author = "Liping Wu and Limin Lu and Long Zhang and Jingkun Xu and Kaixin Zhang and Yangping Wen and Xuemin Duan and Fan Yang",

year = "2013",

month = sep,

doi = "10.1002/elan.201300247",

language = "English",

volume = "25",

pages = "2244--2250",

journal = "Electroanalysis",

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TY - JOUR

T1 - Electrochemical determination of the anticancer herbal drug shikonin at a nanostructured poly(hydroxymethylated-3,4-ethylenedioxythiophene) modified electrode

AU - Wu, Liping

AU - Lu, Limin

AU - Zhang, Long

AU - Xu, Jingkun

AU - Zhang, Kaixin

AU - Wen, Yangping

AU - Duan, Xuemin

AU - Yang, Fan

PY - 2013/9

Y1 - 2013/9

N2 - A simple and sensitive method is described for the electrochemical determination of shikonin, a widely used anti-tumoral agent, based on its electrochemical oxidation at a nanostructured poly(hydroxymethylated-3,4-ethylenedioxy-thiophene) (PEDOT-MeOH) electrode, which was fabricated by a facile electropolymerization method. Compared with bare and poly(3,4-ethylenedioxythiophene) (PEDOT) electrodes, the PEDOT-MeOH film exhibited a distinctly higher activity for the electrooxidation of shikonin. The PEDOT-MeOH electrode showed a wide linear response for shikonin in the concentration range from 1.0nM to 10.0μM with detection limit of 0.3nM. Furthermore, the PEDOT-MeOH electrode displayed high stability, good reproducibility and high sensitivity for the detection of shikonin.

AB - A simple and sensitive method is described for the electrochemical determination of shikonin, a widely used anti-tumoral agent, based on its electrochemical oxidation at a nanostructured poly(hydroxymethylated-3,4-ethylenedioxy-thiophene) (PEDOT-MeOH) electrode, which was fabricated by a facile electropolymerization method. Compared with bare and poly(3,4-ethylenedioxythiophene) (PEDOT) electrodes, the PEDOT-MeOH film exhibited a distinctly higher activity for the electrooxidation of shikonin. The PEDOT-MeOH electrode showed a wide linear response for shikonin in the concentration range from 1.0nM to 10.0μM with detection limit of 0.3nM. Furthermore, the PEDOT-MeOH electrode displayed high stability, good reproducibility and high sensitivity for the detection of shikonin.

KW - PEDOT-MeOH

KW - electropolymerization

KW - shikonin

KW - modified electrode

KW - electrochemical determination

UR - http://www.scopus.com/inward/record.url?scp=84883773604&partnerID=8YFLogxK

U2 - 10.1002/elan.201300247

DO - 10.1002/elan.201300247

M3 - Article

AN - SCOPUS:84883773604

VL - 25

SP - 2244

EP - 2250

JO - Electroanalysis

JF - Electroanalysis

SN - 1040-0397

IS - 9

ER -

Electrochemical determination of the anticancer herbal drug shikonin at a nanostructured poly(hydroxymethylated-3,4-ethylenedioxythiophene) modified electrode

Abstract

Keywords

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