Electrochemical study of amiodarone charge-transfer complexes

Rowena V. Ball, George M. Eckert, Felix Gutmann, Danny K Y Wong*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    16 Citations (Scopus)

    Abstract

    The electron-donating properties of the drug amiodarone (also known as cordarone), have been studied by conductimetry. Amiodarone was found to form a charge-transfer complex in vitro with the electron acceptor iodine, which is involved in human thyroid metabolism. Amiodarone was also found to interact with some other biological molecules with the capacity to behave as electron acceptors, such as dopamine hydrochloride, (-)-epinephrine, serotonin hydrochloride, coenzyme Q(o), and β-nicotinamide adenine dinucleotide. An electronic absorption band in the visible region of the spectrum due to charge-transfer complex formation between iodine and amiodarone was also observed, supporting the conductimetric results.

    Original languageEnglish
    Pages (from-to)1198-1203
    Number of pages6
    JournalAnalytical Chemistry
    Volume66
    Issue number7
    Publication statusPublished - 1994

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