Electrospun Chitosan-graft-PLGA nanofibres with significantly enhanced hydrophilicity and improved mechanical property

Ai D. Li, Z. Z. Sun, M. Zhou, X. X. Xu, J. Y. Ma, W. Zheng*, H. M. Zhou, L. Li, Y. F. Zheng

*Corresponding author for this work

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

This work reported a novel poly(lactic-co-glycolic acid) (PLGA) composite nanofibres, Chitosan-graft-PLGA (CS-graft-PLGA), produced by the electrospinning technique. CS was grafted onto the PLGA surface via the cross-linking agents reacting with the PLGA with reactive carboxyl groups on its surfaces introduced from the alkali treatment. The CS grafting ratios of the electrospun CS-graft-PLGA nanofibres were about 2.43%, 4.34%, 16.97% and 39.4% after cross-linked for 12. h, 16. h, 20. h and 24. h, respectively. The electrospun CS-graft-PLGA nanofibres were significantly uniform and highly smooth without the occurrence of bead defects, even at high CS grafting ratio. The electrospun CS-graft-PLGA nanofibres not only possessed the improved hydrophilicity and the protein absorption property, but also maintained the good mechanical property. In addition, the CS grafting can be conducive to accelerate degradation rate of PLGA.

Original languageEnglish
Pages (from-to)674-681
Number of pages8
JournalColloids and Surfaces B: Biointerfaces
Volume102
DOIs
Publication statusPublished - 1 Feb 2013
Externally publishedYes

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