Elevated serum thyroglobulin levels at the time of ablative radioactive iodine therapy indicate a worse prognosis in thyroid cancer

An Australian retrospective cohort study

T. J. Matthews*, E. Chua, A. Gargya, J. Clark, K. Gao, M. Elliott

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Serum thyroglobulin is used as a surrogate marker for well-differentiated thyroid carcinoma recurrence. This study investigates whether thyroglobulin measured at the time of ablative radioactive iodine therapy predicts disease-free survival. Methods: A retrospective review was conducted of patients with well-differentiated thyroid carcinoma presenting from 1989 to 2010 at the Royal Prince Alfred Hospital, New South Wales, Australia. Disease-free survival of patients with a significantly elevated stimulated thyroglobulin level (27.5 Âg/l or higher) at the time of ablative radioactive iodine therapy was compared to that of patients without a significantly elevated thyroglobulin level using univariate analysis. Results: Patients with a thyroglobulin level of 27.5 Âg/l or higher had an increased relative risk of disease recurrence of 4.50 (95 per cent confidence interval = 1.35-15.04). If lateral neck dissection was required at the time of surgery, patients also had an increased relative risk of macroscopic disease recurrence of 4.94 (95 per cent confidence interval = 1.47-16.55). Conclusion: An elevated thyroglobulin level of 27.5 Âg/l or higher at the time of ablative radioactive iodine therapy is a prognostic indicator for macroscopic disease recurrence in well-differentiated thyroid carcinoma.

Original languageEnglish
Pages (from-to)S50-S53
Number of pages4
JournalJournal of Laryngology and Otology
Volume130
Issue numberSuppl.4
DOIs
Publication statusPublished - 1 Jul 2016
Externally publishedYes

Keywords

  • Biochemical Tumor Markers
  • Disease-Free Survival
  • Iodine
  • Prognosis
  • Thyroglobulin
  • Thyroid Neoplasms

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