Abstract
The isolation of bromotyrosine alkaloids, some of which are enantiomers of previously isolated compounds, has highlighted a possible enantiodivergence in their biosynthesis. Two new (1, 2) and six known bromotyrosine alkaloids (4-9), and the enantiomer (10) of a known compound, have been isolated from a Western Australian marine sponge, Pseudoceratina cf. verrucosa. The compounds inhibited the growth of multidrug-resistant and methicillin-resistant Staphylococcus aureus with comparable activity to vancomycin. In addition, one possible artifact of extraction (3) containing an ethoxy group was isolated. From analysis of the known bromotyrosine alkaloids, a biogenesis is proposed that explains the formation of antipodal natural products within this family of sponges.
| Original language | English |
|---|---|
| Pages (from-to) | 215-219 |
| Number of pages | 5 |
| Journal | Journal of Natural Products |
| Volume | 80 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 27 Jan 2017 |
Bibliographical note
This is the Accepted Manuscript version of the following article: Enantiodivergence in the biosynthesis of bromotyrosine alkaloids from sponges? (2017) Kavita Ragini, Jane Fromont, Andrew M. Piggott, & Peter Karuso, Journal of Natural Products, Vol. 80, No. 1, pp. 215-219.which has been published in final form at:
https://doi.org/10.1021/acs.jnatprod.6b01038
Publisher: American Chemical Society
Copyright: 2017 American Chemical Society