TY - JOUR
T1 - Encapsulation of actives for sustained release
AU - Andersson Trojer, Markus
AU - Nordstierna, Lars
AU - Nordin, Matias
AU - Nydén, Magnus
AU - Holmberg, Krister
PY - 2013/11/7
Y1 - 2013/11/7
N2 - Encapsulation of actives in miniature reservoirs, called microcapsules, is used for protection and in particular controlled release of the active. Regarding controlled release applications, the most common function of the microcapsule is to sustain or extend the release of the active. A number of encapsulation methodologies are available including; internal phase separation, interfacial polymerization, formation of multiple emulsions, Layer-by-Layer adsorption of polyelectrolytes and soft templating techniques, all of which are reviewed in this Perspective. The choice of method depends on the nature of the active (hydrophilic/hydrophobic, size, physical state) and on the intended release rate and release profile. Ways to manipulate the release of the active by tailoring the physicochemical properties of the microcapsule are reviewed. Moreover, appropriate diffusion models are introduced to describe the release profile from a variety of microcapsule morphologies, including Fickian diffusion models and Brownian motion, and the meaning and the misuse of the term "zero-order release" are briefly discussed.
AB - Encapsulation of actives in miniature reservoirs, called microcapsules, is used for protection and in particular controlled release of the active. Regarding controlled release applications, the most common function of the microcapsule is to sustain or extend the release of the active. A number of encapsulation methodologies are available including; internal phase separation, interfacial polymerization, formation of multiple emulsions, Layer-by-Layer adsorption of polyelectrolytes and soft templating techniques, all of which are reviewed in this Perspective. The choice of method depends on the nature of the active (hydrophilic/hydrophobic, size, physical state) and on the intended release rate and release profile. Ways to manipulate the release of the active by tailoring the physicochemical properties of the microcapsule are reviewed. Moreover, appropriate diffusion models are introduced to describe the release profile from a variety of microcapsule morphologies, including Fickian diffusion models and Brownian motion, and the meaning and the misuse of the term "zero-order release" are briefly discussed.
UR - http://www.scopus.com/inward/record.url?scp=84885142743&partnerID=8YFLogxK
U2 - 10.1039/c3cp52686k
DO - 10.1039/c3cp52686k
M3 - Review article
C2 - 23999918
AN - SCOPUS:84885142743
VL - 15
SP - 17727
EP - 17741
JO - Physical Chemistry Chemical Physics
JF - Physical Chemistry Chemical Physics
SN - 1463-9076
IS - 41
ER -