Endobronchial deposits of chronic lymphocytic leukemia - an unusual cause of central airway obstruction

Miranda Maw; Michael Harvey; Zinta Harrington; Melissa Baraket; Renn Montgomery; Jonathan Williamson

doi:10.1002/rcr2.96

Endobronchial deposits of chronic lymphocytic leukemia - an unusual cause of central airway obstruction

Miranda Maw^*, Michael Harvey, Zinta Harrington, Melissa Baraket, Renn Montgomery, Jonathan Williamson

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

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Abstract

A 66-year-old woman with a background of chronic lymphocytic leukemia (CLL) was admitted to the hospital on several occasions with recurrent episodes of community-acquired pneumonia. Computed tomography and bronchoscopy revealed multiple obstructing endobronchial polyps. Post-obstructive pneumonia together with immunoglobulin G deficiency was considered the most likely cause of these recurrent infections. Bronchoscopy was performed for removal of the critically obstructing lesions. Histopathology revealed replacement of bronchial mucosa with CLL deposits. Despite a brief window of infection-free survival following therapy, she remained susceptible to pneumonia with further hospital admissions and eventually died from her disease.

Original language	English
Pages (from-to)	41-43
Number of pages	3
Journal	Respirology Case Reports
Volume	3
Issue number	2
DOIs	https://doi.org/10.1002/rcr2.96
Publication status	Published - Jun 2015
Externally published	Yes

Keywords

Bronchoscopy
Central airway obstruction
Chronic lymphocytic leukemia
Endobronchial deposits

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10.1002/rcr2.96Licence: CC BY

Publisher version (open access)Final published version, 323 KBLicence: CC BY

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title = "Endobronchial deposits of chronic lymphocytic leukemia - an unusual cause of central airway obstruction",

abstract = "A 66-year-old woman with a background of chronic lymphocytic leukemia (CLL) was admitted to the hospital on several occasions with recurrent episodes of community-acquired pneumonia. Computed tomography and bronchoscopy revealed multiple obstructing endobronchial polyps. Post-obstructive pneumonia together with immunoglobulin G deficiency was considered the most likely cause of these recurrent infections. Bronchoscopy was performed for removal of the critically obstructing lesions. Histopathology revealed replacement of bronchial mucosa with CLL deposits. Despite a brief window of infection-free survival following therapy, she remained susceptible to pneumonia with further hospital admissions and eventually died from her disease.",

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AU - Maw, Miranda

AU - Harvey, Michael

AU - Harrington, Zinta

AU - Baraket, Melissa

AU - Montgomery, Renn

AU - Williamson, Jonathan

PY - 2015/6

Y1 - 2015/6

N2 - A 66-year-old woman with a background of chronic lymphocytic leukemia (CLL) was admitted to the hospital on several occasions with recurrent episodes of community-acquired pneumonia. Computed tomography and bronchoscopy revealed multiple obstructing endobronchial polyps. Post-obstructive pneumonia together with immunoglobulin G deficiency was considered the most likely cause of these recurrent infections. Bronchoscopy was performed for removal of the critically obstructing lesions. Histopathology revealed replacement of bronchial mucosa with CLL deposits. Despite a brief window of infection-free survival following therapy, she remained susceptible to pneumonia with further hospital admissions and eventually died from her disease.

AB - A 66-year-old woman with a background of chronic lymphocytic leukemia (CLL) was admitted to the hospital on several occasions with recurrent episodes of community-acquired pneumonia. Computed tomography and bronchoscopy revealed multiple obstructing endobronchial polyps. Post-obstructive pneumonia together with immunoglobulin G deficiency was considered the most likely cause of these recurrent infections. Bronchoscopy was performed for removal of the critically obstructing lesions. Histopathology revealed replacement of bronchial mucosa with CLL deposits. Despite a brief window of infection-free survival following therapy, she remained susceptible to pneumonia with further hospital admissions and eventually died from her disease.

KW - Bronchoscopy

KW - Central airway obstruction

KW - Chronic lymphocytic leukemia

KW - Endobronchial deposits

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EP - 43

JO - Respirology Case Reports

JF - Respirology Case Reports

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ER -

Endobronchial deposits of chronic lymphocytic leukemia - an unusual cause of central airway obstruction

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