TY - JOUR
T1 - Endogenous sex hormones and cognitive function in older women
AU - Koyama, Alain K.
AU - Tworoger, Shelley S.
AU - Eliassen, A. Heather
AU - Okereke, Olivia I.
AU - Weisskopf, Marc G.
AU - Rosner, Bernard
AU - Yaffe, Kristine
AU - Grodstein, Francine
PY - 2016/7
Y1 - 2016/7
N2 - Introduction: We examined the association between endogenous sex hormones and both objective and subjective measures of cognitive function. Methods: We followed 3044 women up to 23 years in a prospective cohort study. We measured plasma levels of estrone, estrone sulfate, estradiol, androstenedione, testosterone, dehydroepiandrosterone (DHEA), and dehydroepiandrosterone sulfate (DHEA-S) in 1989–1990, conducted neuropsychologic testing in 1999–2008, and inquired about subjective cognition in 2012. Results: Overall, we observed little relation between plasma levels of hormones and either neuropsychologic test performance or subjective cognition. However, after adjustment for age and education, we observed a borderline significant association of higher levels of plasma estrone with higher scores for both overall cognition (P trend = .10) and verbal memory (P trend = .08). Discussion: There were no clear associations of endogenous hormone levels at midlife and cognition in later life, although a suggested finding of higher levels of plasma estrone associated with better cognitive function merits further research.
AB - Introduction: We examined the association between endogenous sex hormones and both objective and subjective measures of cognitive function. Methods: We followed 3044 women up to 23 years in a prospective cohort study. We measured plasma levels of estrone, estrone sulfate, estradiol, androstenedione, testosterone, dehydroepiandrosterone (DHEA), and dehydroepiandrosterone sulfate (DHEA-S) in 1989–1990, conducted neuropsychologic testing in 1999–2008, and inquired about subjective cognition in 2012. Results: Overall, we observed little relation between plasma levels of hormones and either neuropsychologic test performance or subjective cognition. However, after adjustment for age and education, we observed a borderline significant association of higher levels of plasma estrone with higher scores for both overall cognition (P trend = .10) and verbal memory (P trend = .08). Discussion: There were no clear associations of endogenous hormone levels at midlife and cognition in later life, although a suggested finding of higher levels of plasma estrone associated with better cognitive function merits further research.
KW - hormones
KW - subjective cognitive complaints
KW - cognition
KW - dementia
KW - Alzheimer's disease
UR - http://www.scopus.com/inward/record.url?scp=84961845487&partnerID=8YFLogxK
U2 - 10.1016/j.jalz.2015.12.010
DO - 10.1016/j.jalz.2015.12.010
M3 - Article
C2 - 26806389
SN - 1552-5260
VL - 12
SP - 758
EP - 765
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 7
ER -