Endoluminal laser-Doppler measurements of jejunal perfusion in patients undergoing liver transplantation

E. Rønholm*, Lars Bäckman, Styrbjørn Friman, Kari Lie Karlsen, Lars Mjörnstedt, Michael Olausson, Anders Åneman

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Patients undergoing liver transplantation are at risk of developing the multiple organ dysfunction syndrome, and attention has been focused on the pathogenic role of decreased gastro-intestinal mucosal perfusion. The aim of this study was to investigate the use of laser-Doppler flowmetry for determination of jejunal perfusion. In 10 patients an endoluminal laser-Doppler catheter was positioned with the tip in the jejunum for continuous measurements of jejunal perfusion. The anhepatic phase was associated with a progressive decrease in jejunal perfusion to 49 (40/65)% (P < 0.01) of dissection phase value. At the end of surgery the jejunal perfusion had increased to 134 (103/158)% (P < 0.01) of dissection phase jejunal perfusion. The endoluminal laser-Doppler technique was found to be easily applicable for continuous monitoring of jejunal perfusion, and the technique could prove valuable in detecting gastro-intestinal hypoperfusion in patients undergoing liver transplantation.

Original languageEnglish
Pages (from-to)24-30
Number of pages7
JournalTransplant International
Volume14
Issue number1
DOIs
Publication statusPublished - 2001

Keywords

  • Intestinal mucosa
  • Laser-Doppler flowmetry
  • Liver transplantation
  • Splanchnic blood flow

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