Endothelial function and dysfunction. Part II

association with cardiovascular risk factors and diseases. A statement by the Working Group on Endothelins and Endothelial Factors of the European Society of Hypertension

Hanspeter Brunner, John R. Cockcroft, John Deanfield, Ann Donald, Ele Ferrannini, Julian Halcox, Wolfgang Kiowski, Thomas F. Lüscher, Giuseppe Mancia, Andrea Natali, James J. Oliver, Achille C. Pessina, Damiano Rizzoni, Gian Paolo Rossi*, Antonio Salvetti, Lukas E. Spieker, Stefano Taddei, David J. Webb

*Corresponding author for this work

Research output: Contribution to journalReview article

551 Citations (Scopus)

Abstract

Dysfunction of the vascular endothelium is a hallmark of most conditions that are associated with atherosclerosis and is therefore held to be an early feature in atherogenesis. However, the mechanisms by which endothelial dysfunction occurs in smoking, dyslipidaemia, hyperhomocysteinaemia, diabetes mellitus, arterial hypertension, cerebrovascular diseases, coronary artery disease and heart failure are complex and heterogeneous. Recent data indicate that endothelial dysfunction is often associated with erectile dysfunction, which can precede and predict cardiovascular disease in men. This paper will provide a concise overview of the mechanisms causing endothelial dysfunction in the different cardiovascular risk factors and disease conditions, and of the impact of the intervention measures and treatments.

Original languageEnglish
Pages (from-to)233-246
Number of pages14
JournalJournal of Hypertension
Volume23
Issue number2
DOIs
Publication statusPublished - Feb 2005

Keywords

  • Cardiovascular disease
  • Cardiovascular risk factors
  • Endothelial dysfunction
  • Endothelial function
  • Nitric oxide
  • Oxidative stress

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