Engineering biocompatible scaffolds through the design of elastin-based short peptides

Md. Musfizur Hassan, Adam D. Martin, Pall Thordarson

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A small library of short peptides has been synthesized based upon the repeat tetrapeptide sequence Gly‐Val‐Ala‐Pro (GVAP) which is found in the hydrophobic domain of tropoelastin. Of the five peptides synthesized, four formed self‐supporting hydrogels with similar secondary structures. The ability to tune the mechanical properties of the resultant hydrogels was demonstrated, and this is understood in relation to fiber bundling. Finally, the cytotoxicity of these elastin‐based short peptide hydrogels towards HeLa cells was assessed, with clear evidence that increased aromaticity of the peptide is detrimental towards cell viability.
Original languageEnglish
Pages (from-to)47-52
Number of pages6
JournalChemPlusChem
Volume83
Issue number1
DOIs
Publication statusPublished - Jan 2018
Externally publishedYes

Keywords

  • cell scaffolds
  • elastin
  • hydrogels
  • peptides
  • supramolecular chemistry

Fingerprint Dive into the research topics of 'Engineering biocompatible scaffolds through the design of elastin-based short peptides'. Together they form a unique fingerprint.

Cite this