Environmental dimensions of antibiotic resistance: assessment of basic science gaps

Kornelia Smalla, Kimberly Cook, Steven P. Djordjevic, Uli Klümper, Michael Gillings

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Antibiotic resistance is one of the major problems facing medical practice in the 21st century. Historical approaches to managing antibiotic resistance have often focused on individual patients, specific pathogens and particular resistance phenotypes. However, it is increasingly recognized that antibiotic resistance is a complex ecological and evolutionary problem. As such, understanding the dynamics of antibiotic resistance requires integration of data on the diverse mobile genetic elements often associated with antibiotic resistance genes, and their dissemination by various mechanisms of horizontal gene transfer between bacterial cells and environments. Most important is understanding the fate and effects of antibiotics at sub-inhibitory concentrations, and co-selection. This opinion paper identifies key knowledge gaps in our understanding of resistance phenomena, and outlines research needs that should be addressed to help us manage resistance into the future.

Original languageEnglish
Article numberfiy195
Pages (from-to)1-6
Number of pages6
JournalFEMS Microbiology Ecology
Volume94
Issue number12
DOIs
Publication statusPublished - 1 Dec 2018

Keywords

  • plasmid
  • insertion element
  • microbiome
  • One Health
  • evolution
  • pathogen

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