Environmental enrichment slows disease progression in R6/2 Huntington's disease mice

Emma Hockly*, Patricia M. Cordery, Benjamin Woodman, Amarbirpal Mahal, Anton Van Dellen, Colin Blakemore, Cathryn M. Lewis, Anthony J. Hannan, Gillian P. Bates

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

283 Citations (Scopus)

Abstract

Huntington's disease is a genetic disorder that causes motor dysfunction, personality changes, dementia, and premature death. There is currently no effective therapy. Several transgenic models of Huntington's disease are available, the most widely used of which is the R6/2 mouse, because of its rapid disease progression. Environmental enrichment alters gene expression in the normal mouse brain, and modulates the course of several neurological disorders. Environmentally enriched mice may actually mimic human disease more accurately. We found that even limited environmental enrichment slows decline in RotaRod performance in R6/2 mice, despite rapid disease progression, whereas in normal littermates, maximal enrichment was required to induce a marked improvement in behavioral tests. Enrichment also delayed the loss of peristriatal cerebral volume in R6/2 brains. These results could provide the basis for a rational approach to ameliorate the effects of Huntington's disease.

Original languageEnglish
Pages (from-to)235-242
Number of pages8
JournalAnnals of Neurology
Volume51
Issue number2
DOIs
Publication statusPublished - 2002
Externally publishedYes

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