Abstract
Inflammatory bowel diseases (IBD) are idiopathic chronic diseases of the gastrointestinal tract well known to be associated with both genetic and environmental risk factors. Permissive genotypes may manifest into clinical phenotypes under certain environmental influences and these may be best studied from migratory studies. Exploring differences between first and second generation migrants may further highlight the contribution of environmental factors towards the development of IBD. There are few opportunities that have been offered so far. We aim to review the available migration studies on IBD, evaluate the known environmental factors associated with IBD, and explore modern migration patterns to identify new opportunities and candidate migrant groups in IBD migration research.
| Original language | English |
|---|---|
| Pages (from-to) | 1238-1247 |
| Number of pages | 10 |
| Journal | World Journal of Gastroenterology |
| Volume | 20 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 7 Feb 2014 |
| Externally published | Yes |
Keywords
- Crohn's disease
- Environment
- Epidemiology
- Hygiene hypothesis
- Inflammatory bowel disease
- Risk factor
- Ulcerative colitis