Epidemiology of dengue in SAARC territory: a systematic review and meta-analysis

Dhan Bahadur Shrestha; Pravash Budhathoki; Bipana Gurung; Subash Subedi; Shishir Aryal; Anisha Basukala; Barun Aryal; Anurag Adhikari; Ayusha Poudel; Gopal Kumar Yadav; Mtanis Khoury; Binod Rayamajhee; Lok Bahadur Shrestha

doi:10.1186/s13071-022-05409-1

Epidemiology of dengue in SAARC territory: a systematic review and meta-analysis

Dhan Bahadur Shrestha, Pravash Budhathoki, Bipana Gurung, Subash Subedi, Shishir Aryal, Anisha Basukala, Barun Aryal, Anurag Adhikari, Ayusha Poudel, Gopal Kumar Yadav, Mtanis Khoury, Binod Rayamajhee, Lok Bahadur Shrestha^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

20 Citations (Scopus)

72 Downloads (Pure)

Abstract

Background: Dengue is one of the common arboviral infections and is a public health problem in South East Asia. The aim of this systematic review and meta-analysis was to evaluate the prevalence and distribution of dengue in SAARC (South Asian Association for Regional Cooperation) countries. Methods: The PubMed, PubMed Central, Embase and Scopus databases were searched for relevant studies. Statistical analysis on data extracted from the selected studied was conducted using the Comprehensive Meta-Analysis Software (CMA) version 3 software package. Proportions were used to estimate the outcome with a 95% confidence interval (CI). Results: Across all studies, among cases of suspected dengue, 30.7% were confirmed dengue cases (proportion: 0.307, 95% CI: 0.277–0.339). The seroprevalence of dengue immunoglobulin (Ig)G, IgM or both (IgM and IgG) antibodies and dengue NS1 antigen was 34.6, 34.2, 29.0 and 24.1%, respectively. Among the different strains of dengue, dengue virus (DENV) strains DENV-1, DENV-2, DENV-3 and DENV-4 accounted for 21.8, 41.2, 14.7 and 6.3% of cases, respectively. The prevalence of dengue fever, dengue hemorrhagic fever and dengue shock syndrome was 80.5, 18.2 and 1.5%, respectively. Fever was a commonly reported symptom, and thrombocytopenia was present in 44.7% of cases. Mortality was reported in 1.9% of dengue cases. Conclusions: Dengue is a common health problem in South East Asia with high seroprevalence. DENV-2 was found to be the most common strain causing infection, and most dengue cases were dengue fever. In addition, thrombocytopenia was reported in almost half of the dengue cases. Graphical Abstract: [Figure not available: see fulltext.].

Original language	English
Article number	389
Pages (from-to)	1-25
Number of pages	25
Journal	Parasites and Vectors
Volume	15
Issue number	1
DOIs	https://doi.org/10.1186/s13071-022-05409-1
Publication status	Published - 24 Oct 2022
Externally published	Yes

Bibliographical note

Copyright the Author(s) 2022. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

Dengue
Dengue fever
Dengue shock syndrome
SAARC region

Access to Document

10.1186/s13071-022-05409-1Licence: CC BY

Publisher version (open access)Final published version, 4.35 MBLicence: CC BY

Cite this

@article{7e77df12ec1e45c58b0301b97f4032f4,

title = "Epidemiology of dengue in SAARC territory: a systematic review and meta-analysis",

abstract = "Background: Dengue is one of the common arboviral infections and is a public health problem in South East Asia. The aim of this systematic review and meta-analysis was to evaluate the prevalence and distribution of dengue in SAARC (South Asian Association for Regional Cooperation) countries. Methods: The PubMed, PubMed Central, Embase and Scopus databases were searched for relevant studies. Statistical analysis on data extracted from the selected studied was conducted using the Comprehensive Meta-Analysis Software (CMA) version 3 software package. Proportions were used to estimate the outcome with a 95\% confidence interval (CI). Results: Across all studies, among cases of suspected dengue, 30.7\% were confirmed dengue cases (proportion: 0.307, 95\% CI: 0.277–0.339). The seroprevalence of dengue immunoglobulin (Ig)G, IgM or both (IgM and IgG) antibodies and dengue NS1 antigen was 34.6, 34.2, 29.0 and 24.1\%, respectively. Among the different strains of dengue, dengue virus (DENV) strains DENV-1, DENV-2, DENV-3 and DENV-4 accounted for 21.8, 41.2, 14.7 and 6.3\% of cases, respectively. The prevalence of dengue fever, dengue hemorrhagic fever and dengue shock syndrome was 80.5, 18.2 and 1.5\%, respectively. Fever was a commonly reported symptom, and thrombocytopenia was present in 44.7\% of cases. Mortality was reported in 1.9\% of dengue cases. Conclusions: Dengue is a common health problem in South East Asia with high seroprevalence. DENV-2 was found to be the most common strain causing infection, and most dengue cases were dengue fever. In addition, thrombocytopenia was reported in almost half of the dengue cases. Graphical Abstract: [Figure not available: see fulltext.].",

keywords = "Dengue, Dengue fever, Dengue shock syndrome, SAARC region",

author = "Shrestha, \{Dhan Bahadur\} and Pravash Budhathoki and Bipana Gurung and Subash Subedi and Shishir Aryal and Anisha Basukala and Barun Aryal and Anurag Adhikari and Ayusha Poudel and Yadav, \{Gopal Kumar\} and Mtanis Khoury and Binod Rayamajhee and Shrestha, \{Lok Bahadur\}",

note = "Copyright the Author(s) 2022. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.",

year = "2022",

month = oct,

day = "24",

doi = "10.1186/s13071-022-05409-1",

language = "English",

volume = "15",

pages = "1--25",

journal = "Parasites and Vectors",

issn = "1756-3305",

publisher = "Springer, Springer Nature",

number = "1",

}

TY - JOUR

T1 - Epidemiology of dengue in SAARC territory

T2 - a systematic review and meta-analysis

AU - Shrestha, Dhan Bahadur

AU - Budhathoki, Pravash

AU - Gurung, Bipana

AU - Subedi, Subash

AU - Aryal, Shishir

AU - Basukala, Anisha

AU - Aryal, Barun

AU - Adhikari, Anurag

AU - Poudel, Ayusha

AU - Yadav, Gopal Kumar

AU - Khoury, Mtanis

AU - Rayamajhee, Binod

AU - Shrestha, Lok Bahadur

N1 - Copyright the Author(s) 2022. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

PY - 2022/10/24

Y1 - 2022/10/24

N2 - Background: Dengue is one of the common arboviral infections and is a public health problem in South East Asia. The aim of this systematic review and meta-analysis was to evaluate the prevalence and distribution of dengue in SAARC (South Asian Association for Regional Cooperation) countries. Methods: The PubMed, PubMed Central, Embase and Scopus databases were searched for relevant studies. Statistical analysis on data extracted from the selected studied was conducted using the Comprehensive Meta-Analysis Software (CMA) version 3 software package. Proportions were used to estimate the outcome with a 95% confidence interval (CI). Results: Across all studies, among cases of suspected dengue, 30.7% were confirmed dengue cases (proportion: 0.307, 95% CI: 0.277–0.339). The seroprevalence of dengue immunoglobulin (Ig)G, IgM or both (IgM and IgG) antibodies and dengue NS1 antigen was 34.6, 34.2, 29.0 and 24.1%, respectively. Among the different strains of dengue, dengue virus (DENV) strains DENV-1, DENV-2, DENV-3 and DENV-4 accounted for 21.8, 41.2, 14.7 and 6.3% of cases, respectively. The prevalence of dengue fever, dengue hemorrhagic fever and dengue shock syndrome was 80.5, 18.2 and 1.5%, respectively. Fever was a commonly reported symptom, and thrombocytopenia was present in 44.7% of cases. Mortality was reported in 1.9% of dengue cases. Conclusions: Dengue is a common health problem in South East Asia with high seroprevalence. DENV-2 was found to be the most common strain causing infection, and most dengue cases were dengue fever. In addition, thrombocytopenia was reported in almost half of the dengue cases. Graphical Abstract: [Figure not available: see fulltext.].

AB - Background: Dengue is one of the common arboviral infections and is a public health problem in South East Asia. The aim of this systematic review and meta-analysis was to evaluate the prevalence and distribution of dengue in SAARC (South Asian Association for Regional Cooperation) countries. Methods: The PubMed, PubMed Central, Embase and Scopus databases were searched for relevant studies. Statistical analysis on data extracted from the selected studied was conducted using the Comprehensive Meta-Analysis Software (CMA) version 3 software package. Proportions were used to estimate the outcome with a 95% confidence interval (CI). Results: Across all studies, among cases of suspected dengue, 30.7% were confirmed dengue cases (proportion: 0.307, 95% CI: 0.277–0.339). The seroprevalence of dengue immunoglobulin (Ig)G, IgM or both (IgM and IgG) antibodies and dengue NS1 antigen was 34.6, 34.2, 29.0 and 24.1%, respectively. Among the different strains of dengue, dengue virus (DENV) strains DENV-1, DENV-2, DENV-3 and DENV-4 accounted for 21.8, 41.2, 14.7 and 6.3% of cases, respectively. The prevalence of dengue fever, dengue hemorrhagic fever and dengue shock syndrome was 80.5, 18.2 and 1.5%, respectively. Fever was a commonly reported symptom, and thrombocytopenia was present in 44.7% of cases. Mortality was reported in 1.9% of dengue cases. Conclusions: Dengue is a common health problem in South East Asia with high seroprevalence. DENV-2 was found to be the most common strain causing infection, and most dengue cases were dengue fever. In addition, thrombocytopenia was reported in almost half of the dengue cases. Graphical Abstract: [Figure not available: see fulltext.].

KW - Dengue

KW - Dengue fever

KW - Dengue shock syndrome

KW - SAARC region

UR - https://www.scopus.com/pages/publications/85140470603

U2 - 10.1186/s13071-022-05409-1

DO - 10.1186/s13071-022-05409-1

M3 - Review article

C2 - 36280877

AN - SCOPUS:85140470603

SN - 1756-3305

VL - 15

SP - 1

EP - 25

JO - Parasites and Vectors

JF - Parasites and Vectors

IS - 1

M1 - 389

ER -

Epidemiology of dengue in SAARC territory: a systematic review and meta-analysis

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this