Epidemiology of inflammatory bowel disease in South America

a systematic review

Sriharan Selvaratnam, Santiago Gullino, Lisa Shim, Eric Lee, Alice Lee, Sudarshan Paramsothy, Rupert W. Leong*

*Corresponding author for this work

Research output: Contribution to journalArticle

3 Citations (Scopus)
8 Downloads (Pure)

Abstract

BACKGROUND The worldwide epidemiology of inflammatory bowel disease (IBD) is rapidly changing. Increasing Crohn's disease (CD) and ulcerative colitis (UC) incidence and prevalence have been recorded in developing regions such as Asia, Africa and Eastern Europe where it was previously thought to be uncommon. Whether this is also the case in South America is not well known. Demonstration that developing regions worldwide have increasing IBD incidence would indicate that environmental change plays a significant role in the development of IBD. AIM To report the incidence, prevalence and disease characteristics of CD and UC within the South American continent. METHODS A systematic review was conducted by searching published studies in major international and regional databases (MEDLINE, EMBASE and Scopus) between January 1990 and December 2018. Outcomes considered were incidence, prevalence, phenotype, environmental and genetic factors, ethnicity and gender. A pair of independent reviewers screened and reviewed all identified articles. RESULTS One hundred and sixty two citations were initially retrieved with 18 studies included in this systematic review. The majority of included studies were from Brazil (n =13, 72%). The incidence of UC ranged from 4.3-5.3/100000 personyears whilst the incidence of CD ranged from 0.74-3.5/100000 person-years. Prevalence ranged from 15.0-24.1/100000 inhabitants for UC and from 2.4- 14.1/100000 inhabitants for CD. The incidence and prevalence of both UC and CD has increased significantly in Brazil over the past 21 years. Pancolitis was the most common disease distribution in patients with UC whilst colonic involvement was the most common distribution in CD. People residing in urban areas were at higher risk of developing both CD and UC. CONCLUSION The IBD burden in South America is increasing at a rate possibly even greater than other developing regions around the world. There is a paucity of highquality epidemiological studies and further robust and representative data are required to further explore modifiable risk factors and disease phenotypes.

Original languageEnglish
Pages (from-to)6866-6875
Number of pages10
JournalWorld Journal of Gastroenterology
Volume25
Issue number47
DOIs
Publication statusPublished - 21 Dec 2019

Bibliographical note

Copyright the Author(s) 2019. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Crohn's disease
  • Epidemiology
  • Inflammatory bowel disease
  • South America
  • Ulcerative colitis

Fingerprint Dive into the research topics of 'Epidemiology of inflammatory bowel disease in South America: a systematic review'. Together they form a unique fingerprint.

Cite this