Epstein‐Barr virus and HIV play no direct role in persistent generalized lymphadenopathy syndrome

M. J. BOYLE, T. B. SCULLEY, D. A. COOPER, J. J. TURNER, R. PENNY, W. A. SEWELL*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

Persistent generalized lymphadenopathy (PGL) and polyclonal B cell activation are features of infection with HIV. Epstein‐Barr virus (EBV) and HIV are known to activate B cells in vitro, but whether they are important B cell activators in patients infected with HIV is less clear. In this study, lymph node tissue was obtained from 10 patients with PGL and assessed for evidence of EBV and HIV gene sequences. DNA was extracted and specific viral gene sequences identified using the polymerase chain reaction (PCR). EBV sequences were difficult to detect in the PGL tissue, with a signal intensity similar to that of other benign and malignant lymphoid conditions not associated with EBV. HIV sequences were also rare in the PGL tissue, consistent with HIV infection of the small number of peripheral blood cells and nodal T cells likely to be present in such a sample. These findings suggest that the polyclonal B cell activation typical of HIV is not driven by direct EBV or HIV infection of B cells.

Original languageEnglish
Pages (from-to)357-361
Number of pages5
JournalClinical & Experimental Immunology
Volume87
Issue number3
DOIs
Publication statusPublished - 1992
Externally publishedYes

Keywords

  • AIDS‐related complex
  • Epstein‐Barr virus
  • lymphadenopathy syndrome HIV

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