ERK inhibition with PD184161 mitigates brain damage in a mouse model of stroke

Amadeus Gladbach, Janet van Eersel, Mian Bi, Yazi D. Ke, Lars M. Ittner*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Ischemic stroke is a leading cause of death. It has previously been shown that blocking activation of extracellular signal-regulated kinase (ERK) with the MEK inhibitor U0126 mitigates brain damage in rodent models of ischemic stroke. Here we show that the newer MEK inhibitor PD184161 reduces cell death and altered gene expression in cultured neurons and mice undergoing excitotoxicity, and has similar protective effects in a mouse model of stroke. This further supports ERK inhibition as a potential treatment for stroke.

Original languageEnglish
Pages (from-to)543-547
Number of pages5
JournalJournal of Neural Transmission
Volume121
Issue number5
DOIs
Publication statusPublished - May 2014
Externally publishedYes

Keywords

  • ERK
  • Glutamate
  • Immediate-early gene
  • MEK inhibitor
  • PD184161
  • Stroke

Fingerprint Dive into the research topics of 'ERK inhibition with PD184161 mitigates brain damage in a mouse model of stroke'. Together they form a unique fingerprint.

Cite this