ERK inhibition with PD184161 mitigates brain damage in a mouse model of stroke

Amadeus Gladbach; Janet van Eersel; Mian Bi; Yazi D. Ke; Lars M. Ittner

doi:10.1007/s00702-013-1138-2

ERK inhibition with PD184161 mitigates brain damage in a mouse model of stroke

Amadeus Gladbach, Janet van Eersel, Mian Bi, Yazi D. Ke, Lars M. Ittner^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Ischemic stroke is a leading cause of death. It has previously been shown that blocking activation of extracellular signal-regulated kinase (ERK) with the MEK inhibitor U0126 mitigates brain damage in rodent models of ischemic stroke. Here we show that the newer MEK inhibitor PD184161 reduces cell death and altered gene expression in cultured neurons and mice undergoing excitotoxicity, and has similar protective effects in a mouse model of stroke. This further supports ERK inhibition as a potential treatment for stroke.

Original language	English
Pages (from-to)	543-547
Number of pages	5
Journal	Journal of Neural Transmission
Volume	121
Issue number	5
DOIs	https://doi.org/10.1007/s00702-013-1138-2
Publication status	Published - May 2014
Externally published	Yes

Keywords

ERK
Glutamate
Immediate-early gene
MEK inhibitor
PD184161
Stroke

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10.1007/s00702-013-1138-2

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AU - Ittner, Lars M.

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KW - Glutamate

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ERK inhibition with PD184161 mitigates brain damage in a mouse model of stroke

Abstract

Keywords

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