Estrogen-related receptor alpha: An orphan finds a family

Aleksandra M. Ochnik, Douglas Yee*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Identification of molecules and their effectors has led to new therapies designed to specifically inhibit pathways in molecularly defined breast cancer subtypes. An orphan nuclear receptor, estrogen-related receptor alpha, has been shown to be a downstream target of two tyrosine kinase growth factor receptors: human epidermal growth factor receptor 2 and the type I insulin-like growth factor receptor. Identifying the mechanistic actions of orphan nuclear receptors could lead to new biomarkers and molecular targets in malignancy.

Original languageEnglish
Article number309
Pages (from-to)1-2
Number of pages2
JournalBreast Cancer Research
Issue number3
Publication statusPublished - 10 May 2012


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