Abstract
Identification of molecules and their effectors has led to new therapies designed to specifically inhibit pathways in molecularly defined breast cancer subtypes. An orphan nuclear receptor, estrogen-related receptor alpha, has been shown to be a downstream target of two tyrosine kinase growth factor receptors: human epidermal growth factor receptor 2 and the type I insulin-like growth factor receptor. Identifying the mechanistic actions of orphan nuclear receptors could lead to new biomarkers and molecular targets in malignancy.
Original language | English |
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Article number | 309 |
Pages (from-to) | 1-2 |
Number of pages | 2 |
Journal | Breast Cancer Research |
Volume | 14 |
Issue number | 3 |
DOIs | |
Publication status | Published - 10 May 2012 |