Ethics, evidence and economics in the pursuit of "personalized medicine"

Jan Lewis, Wendy Lipworth, Ian Kerridge

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)
2 Downloads (Pure)


Despite enthusiastic advocacy for what personalized medicine might be able to deliver and major investments into the development of this, there remain disappointingly few examples of personalized medicine in routine clinical practice today, particularly in high areas of unmet need such as cancer. We believe that this is because personalized medicine challenges the moral, economic and epistemological foundations of medicine. In this article, we briefly describe the scientific premises underpinning personalized medicine, contrast these with traditional paradigms of drug development, and then consider the ethical, economic and epistemological implications of this approach to medicine.

Original languageEnglish
Pages (from-to)137-146
Number of pages10
JournalJournal of Personalized Medicine
Issue number2
Publication statusPublished - 27 Mar 2014
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2014. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.


  • individualized medicine
  • pharmacology
  • ethics
  • economics
  • medicine
  • knowledge


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