Evaluating the temperature effects of ice and heat tests on ptosis due to Myasthenia Gravis

Emmanuel Marinos, Katherine Buzzard, Clare L. Fraser, Stephen Reddel

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Aims: The aims of this study are as follows: (1) to describe a standardised methodology for the ice test, and where necessary a heat test; (2) to determine the effects of local cooling vs. heating on ptosis in myasthenia gravis (MG) patients. Methods: Twenty-three MG patients with ptosis were identified from a tertiary referral neuroimmunology clinic, seventeen with significant ptosis ≥2 mm. Latex party balloons were filled with ice and cold tap water for the ice test, or with water heated to 45 °C for the heat test. Each test was performed for 2 min, with ruler measurement and photographs taken of the palpebral aperture before and immediately after each test. Results: This standardised method was efficient in a clinical setting while maintaining efficacy. In all 23 patients, the mean improvements in ptosis with the ice, rest, and heat tests were 2.3 (±1.5) mm, 1.3 (±1.1) mm, and 0.33 (±1.4) mm respectively. In the 17 patients with significant ptosis, the mean improvements in ptosis with the ice, rest, and heat tests were 2.9 (±1.2) mm, 1.8 (±0.92) mm, and 0.83 (±1.4) mm, respectively. In these 17 patients, the ice test improved ptosis by 1.3 mm more than rest (p < 0.0001). The heat test improved ptosis by 1.1 mm less than rest (p = 0.0013). The ice test improved ptosis by 2.3 mm more than the heat test (p < 0.0001). Conclusions: The standardised methodology of ice and heat testing was safe, easily reproducible and effective. We confirm that temperature had a significant effect on ptosis in MG, and therefore refute the notion that measured changes are purely due to the associated rest.

LanguageEnglish
Pages1387-1391
Number of pages5
JournalEye (Basingstoke)
Volume32
Issue number8
DOIs
Publication statusPublished - 1 Aug 2018

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Myasthenia Gravis
Ice
Hot Temperature
Temperature
Water
Latex
Eyelids
Heating
Referral and Consultation

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Marinos, Emmanuel ; Buzzard, Katherine ; Fraser, Clare L. ; Reddel, Stephen. / Evaluating the temperature effects of ice and heat tests on ptosis due to Myasthenia Gravis. In: Eye (Basingstoke). 2018 ; Vol. 32, No. 8. pp. 1387-1391.
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abstract = "Aims: The aims of this study are as follows: (1) to describe a standardised methodology for the ice test, and where necessary a heat test; (2) to determine the effects of local cooling vs. heating on ptosis in myasthenia gravis (MG) patients. Methods: Twenty-three MG patients with ptosis were identified from a tertiary referral neuroimmunology clinic, seventeen with significant ptosis ≥2 mm. Latex party balloons were filled with ice and cold tap water for the ice test, or with water heated to 45 °C for the heat test. Each test was performed for 2 min, with ruler measurement and photographs taken of the palpebral aperture before and immediately after each test. Results: This standardised method was efficient in a clinical setting while maintaining efficacy. In all 23 patients, the mean improvements in ptosis with the ice, rest, and heat tests were 2.3 (±1.5) mm, 1.3 (±1.1) mm, and 0.33 (±1.4) mm respectively. In the 17 patients with significant ptosis, the mean improvements in ptosis with the ice, rest, and heat tests were 2.9 (±1.2) mm, 1.8 (±0.92) mm, and 0.83 (±1.4) mm, respectively. In these 17 patients, the ice test improved ptosis by 1.3 mm more than rest (p < 0.0001). The heat test improved ptosis by 1.1 mm less than rest (p = 0.0013). The ice test improved ptosis by 2.3 mm more than the heat test (p < 0.0001). Conclusions: The standardised methodology of ice and heat testing was safe, easily reproducible and effective. We confirm that temperature had a significant effect on ptosis in MG, and therefore refute the notion that measured changes are purely due to the associated rest.",
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Evaluating the temperature effects of ice and heat tests on ptosis due to Myasthenia Gravis. / Marinos, Emmanuel; Buzzard, Katherine; Fraser, Clare L.; Reddel, Stephen.

In: Eye (Basingstoke), Vol. 32, No. 8, 01.08.2018, p. 1387-1391.

Research output: Contribution to journalArticleResearchpeer-review

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