Evaluation of a PDMS-based sensor for human CD4+-cell count

Sara Thorslund, Rolf Larsson, Fredrik Nikolajeff, Jonas Bergquist, Javier Sanchez

    Research output: Chapter in Book/Report/Conference proceedingConference proceeding contributionpeer-review

    Abstract

    Up to today, the number of CD4+ lymphocytes remains the most important biological marker to determine the clinical stage of an HIV-infection. Analysis by flow cytometry, the standard method used today, is unsuitable in many developing countries, because of high costs involved and practical inconveniences. We here describe a method where surface modified PDMS captures exclusively CD4+ cells from non-diluted human whole blood. A simple fluorescence microscope for stained leucocytes counting is the only detection equipment needed.

    Original languageEnglish
    Title of host publicationMicro Total Analysis Systems - Proceedings of MicroTAS 2006 Conference: 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences
    PublisherJapan Academic Association Inc
    Pages326-328
    Number of pages3
    Publication statusPublished - 2006
    Event10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006 - Tokyo, Japan
    Duration: 5 Nov 20069 Nov 2006

    Other

    Other10th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2006
    Country/TerritoryJapan
    CityTokyo
    Period5/11/069/11/06

    Keywords

    • CD4 cells
    • Heparin
    • HIV
    • PDMS
    • Point-of-care

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