Evaluation of an OSEM-based PVC method for SPECT with clinical data

Kjell Erlandsson; Benjamin Thomas; John Dickson; Brian F. Hutton

doi:10.1109/NSSMIC.2010.5874278

Evaluation of an OSEM-based PVC method for SPECT with clinical data

Kjell Erlandsson^*, Benjamin Thomas, John Dickson, Brian F. Hutton

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference proceeding contribution › peer-review

3 Citations (Scopus)

Abstract

Partial volume correction (PVC) can compensate for cross-talk between different anatomical regions in images from a functional imaging system with poor spatial resolution, such as PET or SPECT, by utilizing data from a high-resolution structural imaging modality, such as CT or MRI. We have developed a new PVC method for SPECT, and here we present an evaluation of this method using clinical data from [ ¹²³I]-FP-CIT (DATscan) studies. PVC was performed based on MRI data, which were segmented and co-registered to the SPECT data. The correction was applied during OSEM reconstruction, taking into account the distance dependent resolution of the SPECT system. We compared our new method (OSEM-PVC) with OSEM reconstruction with resolution recovery (OSEM-RR). Qualitatively, OSEM-PVC resulted in images with visually improved structural definition and, quantitatively, it gave similar contrast as OSEM-RR but lower intra-region variability.

Original language	English
Title of host publication	IEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010
Pages	2687-2690
Number of pages	4
DOIs	https://doi.org/10.1109/NSSMIC.2010.5874278
Publication status	Published - 2010
Event	2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010 - Knoxville, TN, United States Duration: 30 Oct 2010 → 6 Nov 2010

Other

Other	2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010
Country/Territory	United States
City	Knoxville, TN
Period	30/10/10 → 6/11/10

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title = "Evaluation of an OSEM-based PVC method for SPECT with clinical data",

abstract = "Partial volume correction (PVC) can compensate for cross-talk between different anatomical regions in images from a functional imaging system with poor spatial resolution, such as PET or SPECT, by utilizing data from a high-resolution structural imaging modality, such as CT or MRI. We have developed a new PVC method for SPECT, and here we present an evaluation of this method using clinical data from [ 123I]-FP-CIT (DATscan) studies. PVC was performed based on MRI data, which were segmented and co-registered to the SPECT data. The correction was applied during OSEM reconstruction, taking into account the distance dependent resolution of the SPECT system. We compared our new method (OSEM-PVC) with OSEM reconstruction with resolution recovery (OSEM-RR). Qualitatively, OSEM-PVC resulted in images with visually improved structural definition and, quantitatively, it gave similar contrast as OSEM-RR but lower intra-region variability.",

author = "Kjell Erlandsson and Benjamin Thomas and John Dickson and Hutton, {Brian F.}",

year = "2010",

doi = "10.1109/NSSMIC.2010.5874278",

language = "English",

isbn = "9781424491063",

pages = "2687--2690",

booktitle = "IEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010",

note = "2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010 ; Conference date: 30-10-2010 Through 06-11-2010",

}

Erlandsson, K, Thomas, B, Dickson, J & Hutton, BF 2010, Evaluation of an OSEM-based PVC method for SPECT with clinical data. in IEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010., 5874278, pp. 2687-2690, 2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010, Knoxville, TN, United States, 30/10/10. https://doi.org/10.1109/NSSMIC.2010.5874278

TY - GEN

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AU - Erlandsson, Kjell

AU - Thomas, Benjamin

AU - Dickson, John

AU - Hutton, Brian F.

PY - 2010

Y1 - 2010

N2 - Partial volume correction (PVC) can compensate for cross-talk between different anatomical regions in images from a functional imaging system with poor spatial resolution, such as PET or SPECT, by utilizing data from a high-resolution structural imaging modality, such as CT or MRI. We have developed a new PVC method for SPECT, and here we present an evaluation of this method using clinical data from [ 123I]-FP-CIT (DATscan) studies. PVC was performed based on MRI data, which were segmented and co-registered to the SPECT data. The correction was applied during OSEM reconstruction, taking into account the distance dependent resolution of the SPECT system. We compared our new method (OSEM-PVC) with OSEM reconstruction with resolution recovery (OSEM-RR). Qualitatively, OSEM-PVC resulted in images with visually improved structural definition and, quantitatively, it gave similar contrast as OSEM-RR but lower intra-region variability.

AB - Partial volume correction (PVC) can compensate for cross-talk between different anatomical regions in images from a functional imaging system with poor spatial resolution, such as PET or SPECT, by utilizing data from a high-resolution structural imaging modality, such as CT or MRI. We have developed a new PVC method for SPECT, and here we present an evaluation of this method using clinical data from [ 123I]-FP-CIT (DATscan) studies. PVC was performed based on MRI data, which were segmented and co-registered to the SPECT data. The correction was applied during OSEM reconstruction, taking into account the distance dependent resolution of the SPECT system. We compared our new method (OSEM-PVC) with OSEM reconstruction with resolution recovery (OSEM-RR). Qualitatively, OSEM-PVC resulted in images with visually improved structural definition and, quantitatively, it gave similar contrast as OSEM-RR but lower intra-region variability.

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DO - 10.1109/NSSMIC.2010.5874278

M3 - Conference proceeding contribution

AN - SCOPUS:79960310536

SN - 9781424491063

SP - 2687

EP - 2690

BT - IEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010

T2 - 2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010

Y2 - 30 October 2010 through 6 November 2010

ER -

Evaluation of an OSEM-based PVC method for SPECT with clinical data

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