Partial volume correction (PVC) can compensate for cross-talk between different anatomical regions in images from a functional imaging system with poor spatial resolution, such as PET or SPECT, by utilizing data from a high-resolution structural imaging modality, such as CT or MRI. We have developed a new PVC method for SPECT, and here we present an evaluation of this method using clinical data from [ 123I]-FP-CIT (DATscan) studies. PVC was performed based on MRI data, which were segmented and co-registered to the SPECT data. The correction was applied during OSEM reconstruction, taking into account the distance dependent resolution of the SPECT system. We compared our new method (OSEM-PVC) with OSEM reconstruction with resolution recovery (OSEM-RR). Qualitatively, OSEM-PVC resulted in images with visually improved structural definition and, quantitatively, it gave similar contrast as OSEM-RR but lower intra-region variability.
|Title of host publication||IEEE Nuclear Science Symposuim and Medical Imaging Conference, NSS/MIC 2010|
|Number of pages||4|
|Publication status||Published - 2010|
|Event||2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010 - Knoxville, TN, United States|
Duration: 30 Oct 2010 → 6 Nov 2010
|Other||2010 IEEE Nuclear Science Symposium, Medical Imaging Conference, NSS/MIC 2010 and 17th International Workshop on Room-Temperature Semiconductor X-ray and Gamma-ray Detectors, RTSD 2010|
|Period||30/10/10 → 6/11/10|