Evaluation of phytochemical and pharmacological properties of Dillenia indica Linn. Leaves

U. Bose, K. Gunasekaran*, V. Bala, A. A. Rahman

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The crude methanol extract of the roots of Dillenia indica Linn. (Family: Dilleniaceae) was investigated for its possible analgesic, antidiarrhoeal and GI motility tests in animal models. The extract produced significant writhing inhibition in acetic acid-induced writhing in mice at the oral dose of 250 and 500 mg kg-1 b.wt. (p<0.01) comparable to the standard drug diclofenac sodium at the dose of 25 mg kg-1 of body weight. The crude extract produced significant antidiarrhoeal effect at the dose of 500 mg kg-1 of body weight comparable to that produced by loperamide, used as standard drug. The extract also reduced significantly the charcoal induced Gastro Intestinal (GI) motility in mice; decreased the movement of GI tract in comparison to control animals. This study has found a base stone to step ahead for further researches to make them pharmaceutically useful.

Original languageEnglish
Pages (from-to)222-228
Number of pages7
JournalJournal of Pharmacology and Toxicology
Volume5
Issue number5
DOIs
Publication statusPublished - 2010
Externally publishedYes

Keywords

  • Dillenia indica Linn
  • phytochemical study
  • pharmacological study
  • ethanolic extraction and herb

Fingerprint Dive into the research topics of 'Evaluation of phytochemical and pharmacological properties of <i>Dillenia indica</i> Linn. Leaves'. Together they form a unique fingerprint.

Cite this