Evaluation of phytochemical and pharmacological properties of Dillenia indica Linn. Leaves

U. Bose, K. Gunasekaran*, V. Bala, A. A. Rahman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


The crude methanol extract of the roots of Dillenia indica Linn. (Family: Dilleniaceae) was investigated for its possible analgesic, antidiarrhoeal and GI motility tests in animal models. The extract produced significant writhing inhibition in acetic acid-induced writhing in mice at the oral dose of 250 and 500 mg kg-1 b.wt. (p<0.01) comparable to the standard drug diclofenac sodium at the dose of 25 mg kg-1 of body weight. The crude extract produced significant antidiarrhoeal effect at the dose of 500 mg kg-1 of body weight comparable to that produced by loperamide, used as standard drug. The extract also reduced significantly the charcoal induced Gastro Intestinal (GI) motility in mice; decreased the movement of GI tract in comparison to control animals. This study has found a base stone to step ahead for further researches to make them pharmaceutically useful.

Original languageEnglish
Pages (from-to)222-228
Number of pages7
JournalJournal of Pharmacology and Toxicology
Issue number5
Publication statusPublished - 2010
Externally publishedYes


  • Dillenia indica Linn
  • phytochemical study
  • pharmacological study
  • ethanolic extraction and herb


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