Evidence for a novel biological role for the multifunctional β-1,3-glucan binding protein in shrimp

Priscila Goncalves, Javier Vernal, Rafael Diego Rosa, Gloria Yepiz-Plascencia, Claudia Regina Batista de Souza, Margherita Anna Barracco, Luciane Maria Perazzolo*

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    33 Citations (Scopus)


    β-1,3-Glucan binding proteins (βGBPs) are soluble pattern recognition proteins/receptors that bind to β-1,3-glucans from fungi cell walls. In crustaceans, βGBPs are abundant plasmatic proteins produced by the hepatopancreas, and have been proved to play multiple biological functions. Here, we purified and characterized novel members of the βGBP family from the hemolymph of two Brazilian shrimps, Farfantepenaeus paulensis (FpβGBP) and Litopenaeus schmitti (LsβGBP). As observed for other crustacean species, FpβGBP and LsβGBP are monomeric proteins (∼100. kDa) able to enhance the activation of the prophenoloxidase system, a potent antimicrobial defense conserved in arthropods. More interestingly, we provided here evidence for a novel biological activity for shrimp βGBPs: the agglutination of fungal cells. Finally, we investigated the modulation of the βGBP gene in F. paulensis shrimps experimentally infected with a cognate fungal pathogen, Fusarium solani. From our expression data, βGBP gene is constitutively expressed in hepatopancreas and not modulated upon a non-lethal fungal infection. Herein, we have improved our knowledge about the βGBP family by the characterization of a novel biological role for this multifunctional protein in shrimp.

    Original languageEnglish
    Pages (from-to)363-367
    Number of pages5
    JournalMolecular Immunology
    Issue number3-4
    Publication statusPublished - Jul 2012


    • βGBP
    • Lectin
    • Pattern recognition protein/receptor
    • Prophenoloxidase activating system
    • Shrimp immunity
    • Transcriptional response to fungal infection


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