Evidence for therapeutic drug monitoring of targeted anticancer therapies

Bo Gao, Shang Yeap, Arthur Clements, Bavanthi Balakrishnar, Mark Wong, Howard Gurney*

*Corresponding author for this work

Research output: Contribution to journalReview article

123 Citations (Scopus)

Abstract

Therapeutic drug monitoring (TDM) provides valuable guidance for dose adjustment of antibiotics, immunosuppressives, antiepileptics, and other drugs, but its use for traditional anticancer therapies has been limited. Perhaps the most important obstacle is the impractical requirement of multiple blood samples to adequately define systemic exposure of drugs that have a short elimination half-life and are given by intermittent intravenous injections. However, the newer targeted anticancer therapies have different pharmacokinetic (PK) and dosing characteristics compared with traditional cytotoxic drugs, making it possible to estimate the steady-state drug exposure with a single trough-level measurement. Recent evidence indicates that certain PK parameters, including trough levels, are correlated with clinical outcomes for many of these agents, including imatinib, sunitinib, rituximab, and cetuximab. Although the current evidence is insufficient to mandate TDM in routine practice, a concerted investigation should be encouraged to determine whether the steady-state trough measurements of targeted agents will have a practical place in the clinical care of patients with cancer.

Original languageEnglish
Pages (from-to)4017-4025
Number of pages9
JournalJournal of Clinical Oncology
Volume30
Issue number32
DOIs
Publication statusPublished - 10 Nov 2012
Externally publishedYes

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