Evidence that the butyryl-cholinesterase K variant can protect against late-onset Alzheimer's disease

Simon M. Laws*, Kevin Taddei, Christopher Fisher, David Small, Roger Clarnette, Joachim Hallmayer, William S. Brooks, John B J Kwok, Peter R. Schofield, Samuel E. Gandy, Ralph N. Martins

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

Recent reports indicate that the K variant of the butyrylcholinesterase (BCHE-K) gene may, in some situations, act in synergism with the ε4 allele of apolipoprotein E (ApoE ε4) to increase the risk of Alzheimer's Disease (AD). Determination of the frequency of the BCHE-K genotype in a sample of 237 AD and 347 control cases did not support an association of BCHE-K with an increased risk of AD but, instead suggested a possible protective effect of BCHE-K. Further epidemiological and biological assessment of these subsets will be required in order to confirm this observation and elucidate the pathophysiological role of BCHE-K in AD.

Original languageEnglish
Pages (from-to)219-223
Number of pages5
JournalAlzheimer's Reports
Volume2
Issue number4
Publication statusPublished - 1999
Externally publishedYes

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