Evidence that the butyryl-cholinesterase K variant can protect against late-onset Alzheimer's disease

Simon M. Laws; Kevin Taddei; Christopher Fisher; David Small; Roger Clarnette; Joachim Hallmayer; William S. Brooks; John B J Kwok; Peter R. Schofield; Samuel E. Gandy; Ralph N. Martins

Evidence that the butyryl-cholinesterase K variant can protect against late-onset Alzheimer's disease

Simon M. Laws^*, Kevin Taddei, Christopher Fisher, David Small, Roger Clarnette, Joachim Hallmayer, William S. Brooks, John B J Kwok, Peter R. Schofield, Samuel E. Gandy, Ralph N. Martins

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Recent reports indicate that the K variant of the butyrylcholinesterase (BCHE-K) gene may, in some situations, act in synergism with the ε4 allele of apolipoprotein E (ApoE ε4) to increase the risk of Alzheimer's Disease (AD). Determination of the frequency of the BCHE-K genotype in a sample of 237 AD and 347 control cases did not support an association of BCHE-K with an increased risk of AD but, instead suggested a possible protective effect of BCHE-K. Further epidemiological and biological assessment of these subsets will be required in order to confirm this observation and elucidate the pathophysiological role of BCHE-K in AD.

Original language	English
Pages (from-to)	219-223
Number of pages	5
Journal	Alzheimer's Reports
Volume	2
Issue number	4
Publication status	Published - 1999
Externally published	Yes

Cite this

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title = "Evidence that the butyryl-cholinesterase K variant can protect against late-onset Alzheimer's disease",

abstract = "Recent reports indicate that the K variant of the butyrylcholinesterase (BCHE-K) gene may, in some situations, act in synergism with the ε4 allele of apolipoprotein E (ApoE ε4) to increase the risk of Alzheimer's Disease (AD). Determination of the frequency of the BCHE-K genotype in a sample of 237 AD and 347 control cases did not support an association of BCHE-K with an increased risk of AD but, instead suggested a possible protective effect of BCHE-K. Further epidemiological and biological assessment of these subsets will be required in order to confirm this observation and elucidate the pathophysiological role of BCHE-K in AD.",

author = "Laws, {Simon M.} and Kevin Taddei and Christopher Fisher and David Small and Roger Clarnette and Joachim Hallmayer and Brooks, {William S.} and Kwok, {John B J} and Schofield, {Peter R.} and Gandy, {Samuel E.} and Martins, {Ralph N.}",

year = "1999",

language = "English",

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journal = "Alzheimer's Reports",

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T1 - Evidence that the butyryl-cholinesterase K variant can protect against late-onset Alzheimer's disease

AU - Laws, Simon M.

AU - Taddei, Kevin

AU - Fisher, Christopher

AU - Small, David

AU - Clarnette, Roger

AU - Hallmayer, Joachim

AU - Brooks, William S.

AU - Kwok, John B J

AU - Schofield, Peter R.

AU - Gandy, Samuel E.

AU - Martins, Ralph N.

PY - 1999

Y1 - 1999

N2 - Recent reports indicate that the K variant of the butyrylcholinesterase (BCHE-K) gene may, in some situations, act in synergism with the ε4 allele of apolipoprotein E (ApoE ε4) to increase the risk of Alzheimer's Disease (AD). Determination of the frequency of the BCHE-K genotype in a sample of 237 AD and 347 control cases did not support an association of BCHE-K with an increased risk of AD but, instead suggested a possible protective effect of BCHE-K. Further epidemiological and biological assessment of these subsets will be required in order to confirm this observation and elucidate the pathophysiological role of BCHE-K in AD.

AB - Recent reports indicate that the K variant of the butyrylcholinesterase (BCHE-K) gene may, in some situations, act in synergism with the ε4 allele of apolipoprotein E (ApoE ε4) to increase the risk of Alzheimer's Disease (AD). Determination of the frequency of the BCHE-K genotype in a sample of 237 AD and 347 control cases did not support an association of BCHE-K with an increased risk of AD but, instead suggested a possible protective effect of BCHE-K. Further epidemiological and biological assessment of these subsets will be required in order to confirm this observation and elucidate the pathophysiological role of BCHE-K in AD.

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M3 - Article

AN - SCOPUS:0043119645

SN - 1461-6130

VL - 2

SP - 219

EP - 223

JO - Alzheimer's Reports

JF - Alzheimer's Reports

IS - 4

ER -

Evidence that the butyryl-cholinesterase K variant can protect against late-onset Alzheimer's disease

Abstract

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