Evolution of pancreas transplant surgery

Vincent W. T. Lam, Henry C. C. Pleass, Wayne Hawthorne, Richard D. M. Allen

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Background: Type 1 diabetes mellitus is a chronic condition often leading to disabling complications including retinopathy, neuropathy and cardiovascular disease which can be modified by intensive treatment with insulin. Such treatment, however, is associated with a restrictive lifestyle and risk of hypoglycaemic morbidity and mortality. Methods: This review examines the role of pancreas transplantation in patients with Type 1 diabetes mellitus. Results: Pancreas transplantation is currently the only proven option to achieve long-term insulin independence, resulting in an improvement or stabilization of those diabetic related complications. The hazards of pancreas transplantation as a major operation are well known. Balancing the risks of a surgical procedure, with the benefits of restoring normoglycaemia remains an important task for the pancreas transplant surgeon. Pancreas transplantation is not an emergency operation to treat poorly managed and non-compliant patients with debilitating complications. It is a highly specialized procedure which has evolved both in terms of the surgical technique, patient selection and assessment. Conclusion: Pancreas transplantation has emerged as the single most effective way to achieve normal glucose homeostasis in patients with Type 1 diabetes mellitus.

Original languageEnglish
Pages (from-to)411-418
Number of pages8
JournalANZ Journal of Surgery
Volume80
Issue number6
DOIs
Publication statusPublished - 1 Jun 2010
Externally publishedYes

Keywords

  • Diabetes mellitus
  • Kidney transplantation
  • Pancreas transplantation

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