Evolution of reticular pseudodrusen

John Sarks*, Jennifer Arnold, I. Van Ho, Shirley Sarks, Murray Killingsworth

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

117 Citations (Scopus)


Aims: To report observations relating to the clinical recognition and possible basis of reticular pseudodrusen (RPD). Methods: This retrospective study reports the evolution of RPD in 166 patients who had follow-up of over 1 year using multiple imaging techniques. Mean age when first seen was 73.3 years and the mean period of observation was 4.9 years (range 1-18 years). Associated macular changes were recorded. Results: RPD were first identified in the upper fundus as a reticular network, which then became less obvious, developing a diffuse yellowish appearance. RPD also faded around choroidal neovascularisation (CNV). RPD therefore could be transient but the pattern often remained visible outside the macula or nasal to the discs. Manifestations of age-related macular degeneration (AMD) were present in nearly all eyes and there was a particularly high association with CNV (52.1%). In one clinicopathological case abnormal material was found in the subretinal space. Conclusions: The prevalence of RPD may be underestimated because their recognition depends upon the imaging method used, the area of fundus examined and the confusion with typical drusen. The pathology of one eye suggests that RPD may correspond to material in the subretinal space.

Original languageEnglish
Pages (from-to)979-985
Number of pages7
JournalBritish Journal of Ophthalmology
Issue number7
Publication statusPublished - Jul 2011
Externally publishedYes


Dive into the research topics of 'Evolution of reticular pseudodrusen'. Together they form a unique fingerprint.

Cite this