TY - JOUR
T1 - Evolution of reticular pseudodrusen
AU - Sarks, John
AU - Arnold, Jennifer
AU - Ho, I. Van
AU - Sarks, Shirley
AU - Killingsworth, Murray
PY - 2011/7
Y1 - 2011/7
N2 - Aims: To report observations relating to the clinical recognition and possible basis of reticular pseudodrusen (RPD). Methods: This retrospective study reports the evolution of RPD in 166 patients who had follow-up of over 1 year using multiple imaging techniques. Mean age when first seen was 73.3 years and the mean period of observation was 4.9 years (range 1-18 years). Associated macular changes were recorded. Results: RPD were first identified in the upper fundus as a reticular network, which then became less obvious, developing a diffuse yellowish appearance. RPD also faded around choroidal neovascularisation (CNV). RPD therefore could be transient but the pattern often remained visible outside the macula or nasal to the discs. Manifestations of age-related macular degeneration (AMD) were present in nearly all eyes and there was a particularly high association with CNV (52.1%). In one clinicopathological case abnormal material was found in the subretinal space. Conclusions: The prevalence of RPD may be underestimated because their recognition depends upon the imaging method used, the area of fundus examined and the confusion with typical drusen. The pathology of one eye suggests that RPD may correspond to material in the subretinal space.
AB - Aims: To report observations relating to the clinical recognition and possible basis of reticular pseudodrusen (RPD). Methods: This retrospective study reports the evolution of RPD in 166 patients who had follow-up of over 1 year using multiple imaging techniques. Mean age when first seen was 73.3 years and the mean period of observation was 4.9 years (range 1-18 years). Associated macular changes were recorded. Results: RPD were first identified in the upper fundus as a reticular network, which then became less obvious, developing a diffuse yellowish appearance. RPD also faded around choroidal neovascularisation (CNV). RPD therefore could be transient but the pattern often remained visible outside the macula or nasal to the discs. Manifestations of age-related macular degeneration (AMD) were present in nearly all eyes and there was a particularly high association with CNV (52.1%). In one clinicopathological case abnormal material was found in the subretinal space. Conclusions: The prevalence of RPD may be underestimated because their recognition depends upon the imaging method used, the area of fundus examined and the confusion with typical drusen. The pathology of one eye suggests that RPD may correspond to material in the subretinal space.
UR - http://www.scopus.com/inward/record.url?scp=79959352037&partnerID=8YFLogxK
U2 - 10.1136/bjo.2010.194977
DO - 10.1136/bjo.2010.194977
M3 - Article
C2 - 21109695
AN - SCOPUS:79959352037
VL - 95
SP - 979
EP - 985
JO - British Journal of Ophthalmology
JF - British Journal of Ophthalmology
SN - 0007-1161
IS - 7
ER -