TY - GEN
T1 - Evolutionary computation for the design of a stochastic switch for synthetic genetic circuits
AU - Hallinan, Jennifer S.
AU - Misirli, Goksel
AU - Wipat, Anil
PY - 2010
Y1 - 2010
N2 - Biological systems are inherently stochastic, a fact which is often ignored when simulating genetic circuits. Synthetic biology aims to design genetic circuits de novo, and cannot therefore afford to ignore the effects of stochastic behavior. Since computational design tools will be essential for large-scale synthetic biology, it is important to develop an understanding of the role of stochasticity in molecular biology, and incorporate this understanding into computational tools for genetic circuit design. We report upon an investigation into the combination of evolutionary algorithms and stochastic simulation for genetic circuit design, to design regulatory systems based on the Bacillus subtilis sin operon.
AB - Biological systems are inherently stochastic, a fact which is often ignored when simulating genetic circuits. Synthetic biology aims to design genetic circuits de novo, and cannot therefore afford to ignore the effects of stochastic behavior. Since computational design tools will be essential for large-scale synthetic biology, it is important to develop an understanding of the role of stochasticity in molecular biology, and incorporate this understanding into computational tools for genetic circuit design. We report upon an investigation into the combination of evolutionary algorithms and stochastic simulation for genetic circuit design, to design regulatory systems based on the Bacillus subtilis sin operon.
UR - http://www.scopus.com/inward/record.url?scp=84903861887&partnerID=8YFLogxK
U2 - 10.1109/IEMBS.2010.5626353
DO - 10.1109/IEMBS.2010.5626353
M3 - Conference proceeding contribution
C2 - 21095906
AN - SCOPUS:78650836055
SN - 9781424441235
T3 - Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society
SP - 768
EP - 774
BT - 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC 2010)
PB - Institute of Electrical and Electronics Engineers (IEEE)
CY - Piscataway, NJ
T2 - 2010 32nd Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBC'10
Y2 - 31 August 2010 through 4 September 2010
ER -