Ewing's sarcoma: a trial of adjuvant chemotherapy and sequential half-body irradiation

Martin P. Berry; R. Derek T. Jenkin; Andrew R. Harwood; Bernard J. Cummings; Ian C. Quirt; Marilyn J. Sonley; Walter D. Rider

doi:10.1016/0360-3016(86)90410-4

Ewing's sarcoma: a trial of adjuvant chemotherapy and sequential half-body irradiation

Martin P. Berry, R. Derek T. Jenkin^*, Andrew R. Harwood, Bernard J. Cummings, Ian C. Quirt, Marilyn J. Sonley, Walter D. Rider

^*Corresponding author for this work

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12 Citations (Scopus)

Abstract

The results of a pilot study using adjuvant chemotherapy and sequential half-body irradiation (HBI) for nonmetastatic Ewing's sarcoma are presented. Seventeen patients received Cyclophosphamide, Vincristine, and Adriamycin (8 cycles), followed by sequential radiation treatment of the upper (500 cGy) and lower (600 cGy) half body. Survival at 3 years was 49%. These results are contrasted with those for 18 concurrently treated patients who received standard adjuvant therapy. Overall 5-year survival and relapse-free survival for these 35 consecutive patients was 61 and 53%. The pilot protocol was given on an out-patient basis with limited and acceptable acute toxicology. Further study is necessary to determine the value of the pilot protocol.

Original language	English
Pages (from-to)	19-24
Number of pages	6
Journal	International Journal of Radiation Oncology, Biology, Physics
Volume	12
Issue number	1
DOIs	https://doi.org/10.1016/0360-3016(86)90410-4
Publication status	Published - 1986

Keywords

Ewing's sarcoma
Sequential half-body irradiation (HBI)
Total body irradiation (TBI)

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10.1016/0360-3016(86)90410-4

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@article{401fdf0cf6a9425184ee45069db5c816,

title = "Ewing's sarcoma: a trial of adjuvant chemotherapy and sequential half-body irradiation",

abstract = "The results of a pilot study using adjuvant chemotherapy and sequential half-body irradiation (HBI) for nonmetastatic Ewing's sarcoma are presented. Seventeen patients received Cyclophosphamide, Vincristine, and Adriamycin (8 cycles), followed by sequential radiation treatment of the upper (500 cGy) and lower (600 cGy) half body. Survival at 3 years was 49%. These results are contrasted with those for 18 concurrently treated patients who received standard adjuvant therapy. Overall 5-year survival and relapse-free survival for these 35 consecutive patients was 61 and 53%. The pilot protocol was given on an out-patient basis with limited and acceptable acute toxicology. Further study is necessary to determine the value of the pilot protocol.",

keywords = "Ewing's sarcoma, Sequential half-body irradiation (HBI), Total body irradiation (TBI)",

author = "Berry, {Martin P.} and Jenkin, {R. Derek T.} and Harwood, {Andrew R.} and Cummings, {Bernard J.} and Quirt, {Ian C.} and Sonley, {Marilyn J.} and Rider, {Walter D.}",

year = "1986",

doi = "10.1016/0360-3016(86)90410-4",

language = "English",

volume = "12",

pages = "19--24",

journal = "International Journal of Radiation Oncology, Biology, Physics",

issn = "0360-3016",

publisher = "Elsevier",

number = "1",

}

Ewing's sarcoma : a trial of adjuvant chemotherapy and sequential half-body irradiation. / Berry, Martin P.; Jenkin, R. Derek T.; Harwood, Andrew R.; Cummings, Bernard J.; Quirt, Ian C.; Sonley, Marilyn J.; Rider, Walter D.

In: International Journal of Radiation Oncology, Biology, Physics, Vol. 12, No. 1, 1986, p. 19-24.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Ewing's sarcoma

T2 - a trial of adjuvant chemotherapy and sequential half-body irradiation

AU - Berry, Martin P.

AU - Jenkin, R. Derek T.

AU - Harwood, Andrew R.

AU - Cummings, Bernard J.

AU - Quirt, Ian C.

AU - Sonley, Marilyn J.

AU - Rider, Walter D.

PY - 1986

Y1 - 1986

N2 - The results of a pilot study using adjuvant chemotherapy and sequential half-body irradiation (HBI) for nonmetastatic Ewing's sarcoma are presented. Seventeen patients received Cyclophosphamide, Vincristine, and Adriamycin (8 cycles), followed by sequential radiation treatment of the upper (500 cGy) and lower (600 cGy) half body. Survival at 3 years was 49%. These results are contrasted with those for 18 concurrently treated patients who received standard adjuvant therapy. Overall 5-year survival and relapse-free survival for these 35 consecutive patients was 61 and 53%. The pilot protocol was given on an out-patient basis with limited and acceptable acute toxicology. Further study is necessary to determine the value of the pilot protocol.

AB - The results of a pilot study using adjuvant chemotherapy and sequential half-body irradiation (HBI) for nonmetastatic Ewing's sarcoma are presented. Seventeen patients received Cyclophosphamide, Vincristine, and Adriamycin (8 cycles), followed by sequential radiation treatment of the upper (500 cGy) and lower (600 cGy) half body. Survival at 3 years was 49%. These results are contrasted with those for 18 concurrently treated patients who received standard adjuvant therapy. Overall 5-year survival and relapse-free survival for these 35 consecutive patients was 61 and 53%. The pilot protocol was given on an out-patient basis with limited and acceptable acute toxicology. Further study is necessary to determine the value of the pilot protocol.

KW - Ewing's sarcoma

KW - Sequential half-body irradiation (HBI)

KW - Total body irradiation (TBI)

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U2 - 10.1016/0360-3016(86)90410-4

DO - 10.1016/0360-3016(86)90410-4

M3 - Article

C2 - 3943988

AN - SCOPUS:0022653817

VL - 12

SP - 19

EP - 24

JO - International Journal of Radiation Oncology, Biology, Physics

JF - International Journal of Radiation Oncology, Biology, Physics

SN - 0360-3016

IS - 1

ER -

Ewing's sarcoma: a trial of adjuvant chemotherapy and sequential half-body irradiation

Abstract

Keywords

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