Examination of the stability of chloral hydrate and its preparation by capillary electrophoresis

K. Kakehi*, M. Nakano, S. Nishiura, S. Tachibana, S. Ishida, M. Taneda

*Corresponding author for this work

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    Abstract

    Stabilities of chloral hydrate in an aqueous solution and its medicated syrup were examined by high performance capillary electrophoresis. Analysis of the concentration of chloral hydrate indicated that there was no obvious change in the concentration of chloral hydrate both in the aqueous solution and in the syrup preparation after keeping them for 3 months at room temperature or at 60°C. The lowering of pit was more obvious in the syrup solution than in the aqueous solution, and this tendency was estimated to be due to the formation of hydrochloric acid. We propose that the stabilities of the preparation of chloral hydrate should be monitored by observing pH changes.

    Original languageEnglish
    Pages (from-to)410-416
    Number of pages7
    JournalYakugaku Zasshi
    Volume119
    Issue number5
    Publication statusPublished - 1999

    Keywords

    • Capillary electrophoresis
    • Chloral hydrate
    • Chloride ion
    • Syrup
    • Trichloroacetic acid

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