TY - JOUR
T1 - Excellent outcomes for adolescents and adults with acute lymphoblastic leukemia and lymphoma without allogeneic stem cell transplant
T2 - the FRALLE-93 pediatric protocol
AU - Hocking, Jay
AU - Schwarer, Anthony P.
AU - Gasiorowski, Robin
AU - Patil, Sush
AU - Avery, Sharon
AU - Gibson, John
AU - Iland, Harry
AU - Ho, P. Joy
AU - Joshua, Douglas
AU - Muirhead, Jenny
AU - Lai, Hock
AU - Irving, Ian
PY - 2014/12
Y1 - 2014/12
N2 - Adolescents and adults with acute lymphoblastic leukemia/lymphoma (ALL) have better outcomes when treated using pediatric protocols compared with treatment using adult protocols. We reviewed the progress and outcomes of 40 adolescents and adults up to 45 years of age, from three Australian centers, treated on the intensive French group for childhood ALL (FRALLE)-93 pediatric protocol. All except one patient achieved a morphologic complete remission following induction chemotherapy. Three-year overall survival for all-risk and standard-risk disease was 70% and 75%, respectively. The treatment protocol was generally well tolerated with no treatment related mortality. The FRALLE-93 pediatric protocol showed excellent overall survival for patients with standard-risk disease, without the need for allogeneic hematopoietic stem cell transplant in first remission.
AB - Adolescents and adults with acute lymphoblastic leukemia/lymphoma (ALL) have better outcomes when treated using pediatric protocols compared with treatment using adult protocols. We reviewed the progress and outcomes of 40 adolescents and adults up to 45 years of age, from three Australian centers, treated on the intensive French group for childhood ALL (FRALLE)-93 pediatric protocol. All except one patient achieved a morphologic complete remission following induction chemotherapy. Three-year overall survival for all-risk and standard-risk disease was 70% and 75%, respectively. The treatment protocol was generally well tolerated with no treatment related mortality. The FRALLE-93 pediatric protocol showed excellent overall survival for patients with standard-risk disease, without the need for allogeneic hematopoietic stem cell transplant in first remission.
KW - Acute lymphoblastic leukemia
KW - Adults
KW - Chemotherapy protocol
KW - Disease risk
KW - Overall survival
UR - http://www.scopus.com/inward/record.url?scp=84919461554&partnerID=8YFLogxK
U2 - 10.3109/10428194.2014.894191
DO - 10.3109/10428194.2014.894191
M3 - Article
C2 - 24528220
SN - 1042-8194
VL - 55
SP - 2801
EP - 2807
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 12
ER -