Excellent outcomes for adolescents and adults with acute lymphoblastic leukemia and lymphoma without allogeneic stem cell transplant: the FRALLE-93 pediatric protocol

Jay Hocking, Anthony P. Schwarer, Robin Gasiorowski, Sush Patil, Sharon Avery, John Gibson, Harry Iland, P. Joy Ho, Douglas Joshua, Jenny Muirhead, Hock Lai, Ian Irving

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Adolescents and adults with acute lymphoblastic leukemia/lymphoma (ALL) have better outcomes when treated using pediatric protocols compared with treatment using adult protocols. We reviewed the progress and outcomes of 40 adolescents and adults up to 45 years of age, from three Australian centers, treated on the intensive French group for childhood ALL (FRALLE)-93 pediatric protocol. All except one patient achieved a morphologic complete remission following induction chemotherapy. Three-year overall survival for all-risk and standard-risk disease was 70% and 75%, respectively. The treatment protocol was generally well tolerated with no treatment related mortality. The FRALLE-93 pediatric protocol showed excellent overall survival for patients with standard-risk disease, without the need for allogeneic hematopoietic stem cell transplant in first remission.
Original languageEnglish
Pages (from-to)2801-2807
Number of pages7
JournalLeukemia and Lymphoma
Volume55
Issue number12
DOIs
Publication statusPublished - Dec 2014
Externally publishedYes

Keywords

  • Acute lymphoblastic leukemia
  • Adults
  • Chemotherapy protocol
  • Disease risk
  • Overall survival

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