Exceptionally strong hydrogels through self-assembly of an indole-capped dipeptide

Adam D. Martin; Andrew B. Robinson; Alexander F. Mason; Jonathan P. Wojciechowski; Pall Thordarson

doi:10.1039/c4cc07941h

Exceptionally strong hydrogels through self-assembly of an indole-capped dipeptide

Adam D. Martin, Andrew B. Robinson, Alexander F. Mason, Jonathan P. Wojciechowski, Pall Thordarson

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

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Abstract

The synthesis of a new hydrogelator with an indole capping group, 1, is reported. 1 forms exceptionally strong hydrogels in a variety of environments, with values for the storage modulus G′ amongst the highest reported for supramolecular hydrogels. These gels exhibit strong bundling characteristics, which gives the high values for G′ observed. Cell viability studies show that at low concentrations, 1 is biocompatible, however upon self-assembly at higher concentrations, cytotoxic effects are observed.

Original language	English
Pages (from-to)	15541-15544
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	98
DOIs	https://doi.org/10.1039/c4cc07941h
Publication status	Published - 2014
Externally published	Yes

Bibliographical note

Copyright The Royal Society of Chemistry 2014. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

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10.1039/c4cc07941h

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Cite this

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AU - Robinson, Andrew B.

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AU - Wojciechowski, Jonathan P.

AU - Thordarson, Pall

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N2 - The synthesis of a new hydrogelator with an indole capping group, 1, is reported. 1 forms exceptionally strong hydrogels in a variety of environments, with values for the storage modulus G′ amongst the highest reported for supramolecular hydrogels. These gels exhibit strong bundling characteristics, which gives the high values for G′ observed. Cell viability studies show that at low concentrations, 1 is biocompatible, however upon self-assembly at higher concentrations, cytotoxic effects are observed.

AB - The synthesis of a new hydrogelator with an indole capping group, 1, is reported. 1 forms exceptionally strong hydrogels in a variety of environments, with values for the storage modulus G′ amongst the highest reported for supramolecular hydrogels. These gels exhibit strong bundling characteristics, which gives the high values for G′ observed. Cell viability studies show that at low concentrations, 1 is biocompatible, however upon self-assembly at higher concentrations, cytotoxic effects are observed.

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JF - Chemical Communications

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Exceptionally strong hydrogels through self-assembly of an indole-capped dipeptide

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