Excess mortality among adults hospitalized with traumatic brain injury in Australia: a population-based matched cohort study

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Objective: To quantify and describe excess mortality attributable to traumatic brain injury (TBI) during the 12 months after hospitalization. Design: Population-based matched cohort study using linked hospital and mortality data. Setting: Australia. Participants: Individuals 18 years and older who were hospitalized with a principal diagnosis of TBI in 2009 (n = 6929) and matched noninjured individuals randomly selected from the electoral roll (n = 6929). Main measures: Survival distributions were compared using a Kaplan-Meier plot with a log-rank test. Mortality rate ratios (MRRs) were computed using Cox proportional hazard regression with and without controlling for demographic characteristics and preexisting health status. Results: Individuals with TBI experienced significantly worse survival during the 12 months after hospitalization (χ2 = 640.9, df = 1, P < .001), and were more than 7.5 times more likely to die compared with their noninjured counterparts (adjusted MRR, 7.76; 95% confidence interval, 6.07-9.93). TBI was likely to be a contributory factor in 87% of deaths in the TBI cohort. Excess mortality was higher among males, younger age groups, and those with more severe TBI. Conclusion: Excess mortality is high among individuals hospitalized with TBI and most deaths are attributable to the TBI. Increased primary and secondary preventive efforts are warranted to reduce the mortality burden of TBI.
LanguageEnglish
PagesE1–E9
Number of pages9
JournalJournal of Head Trauma Rehabilitation
Volume34
Issue number3
Early online date8 Nov 2018
DOIs
Publication statusPublished - May 2019

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Cohort Studies
Mortality
Population
Hospitalization
Traumatic Brain Injury
Survival
Hospital Mortality
Health Status
Age Groups
Demography
Confidence Intervals

Keywords

  • comorbidity
  • data linkage
  • mortality
  • survival
  • traumatic brain injury

Cite this

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title = "Excess mortality among adults hospitalized with traumatic brain injury in Australia: a population-based matched cohort study",
abstract = "Objective: To quantify and describe excess mortality attributable to traumatic brain injury (TBI) during the 12 months after hospitalization. Design: Population-based matched cohort study using linked hospital and mortality data. Setting: Australia. Participants: Individuals 18 years and older who were hospitalized with a principal diagnosis of TBI in 2009 (n = 6929) and matched noninjured individuals randomly selected from the electoral roll (n = 6929). Main measures: Survival distributions were compared using a Kaplan-Meier plot with a log-rank test. Mortality rate ratios (MRRs) were computed using Cox proportional hazard regression with and without controlling for demographic characteristics and preexisting health status. Results: Individuals with TBI experienced significantly worse survival during the 12 months after hospitalization (χ2 = 640.9, df = 1, P < .001), and were more than 7.5 times more likely to die compared with their noninjured counterparts (adjusted MRR, 7.76; 95{\%} confidence interval, 6.07-9.93). TBI was likely to be a contributory factor in 87{\%} of deaths in the TBI cohort. Excess mortality was higher among males, younger age groups, and those with more severe TBI. Conclusion: Excess mortality is high among individuals hospitalized with TBI and most deaths are attributable to the TBI. Increased primary and secondary preventive efforts are warranted to reduce the mortality burden of TBI.",
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Excess mortality among adults hospitalized with traumatic brain injury in Australia : a population-based matched cohort study. / Lystad, Reidar P.; Cameron, Cate; Mitchell, Rebecca.

In: Journal of Head Trauma Rehabilitation, Vol. 34, No. 3, 05.2019, p. E1–E9.

Research output: Contribution to journalArticleResearchpeer-review

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