Excessive respiratory modulation of blood pressure triggers hypertension

Clément Menuet, Sheng Le, Bowen Dempsey, Angela A. Connelly, Jessica L. Kamar, Nikola Jancovski, Jaspreet K. Bassi, Keryn Walters, Annabel E. Simms, Andrew Hammond, Angelina Y. Fong, Ann K. Goodchild, Simon McMullan, Andrew M. Allen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

33 Citations (Scopus)

Abstract

The etiology of hypertension, the world’s biggest killer, remains poorly understood, with treatments targeting the established symptom, not the cause. The development of hypertension involves increased sympathetic nerve activity that, in experimental hypertension, may be driven by excessive respiratory modulation. Using selective viral and cell lesion techniques, we identify adrenergic C1 neurons in the medulla oblongata as critical for respiratory-sympathetic entrainment and the development of experimental hypertension. We also show that a cohort of young, normotensive humans, selected for an exaggerated blood pressure response to exercise and thus increased hypertension risk, has enhanced respiratory-related blood pressure fluctuations. These studies pinpoint a specific neuronal target for ameliorating excessive sympathetic activity during the developmental phase of hypertension and identify a group of pre-hypertensive subjects that would benefit from targeting these cells.
Original languageEnglish
Pages (from-to)739-748
Number of pages10
JournalCell Metabolism
Volume25
Issue number3
DOIs
Publication statusPublished - 7 Mar 2017

Fingerprint Dive into the research topics of 'Excessive respiratory modulation of blood pressure triggers hypertension'. Together they form a unique fingerprint.

Cite this