Excitation of neurones in a restricted portion of the midbrain periaqueductal grey elicits both behavioural and cardiovascular components of the defence reaction in the unanaesthetised decerebrate cat

Pascal Carrive, Roger A L Dampney*, Richard Bandler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

128 Citations (Scopus)

Abstract

Microinjections of the excitant amino acid d,l-homocysteic acid (DLH) into a restricted part of the midbrain periaqueductal grey (PAG) of unanaesthetized decerebrate cats evoked a distinctive pattern of facio-vocal and cardiovascular changes characteristic of a defence reaction, including pupillary dilatation, howling vocalization, an increase in arterial pressure and heart rate, and skeletal muscle vasoconstriction. These facio-vocal and cardiovascular responses always occurred together, and thus may arise from excitation of a common population of neurones. DLH injections within a greater extent of the PAG elicited other facio-vocal changes characteristic of defence, such as hissing or growling, but these were not accompanied by significant cardiovascular changes.

Original languageEnglish
Pages (from-to)273-278
Number of pages6
JournalNeuroscience Letters
Volume81
Issue number3
DOIs
Publication statusPublished - 29 Oct 1987
Externally publishedYes

Keywords

  • Blood pressure
  • Cat
  • Defence reaction
  • Excitatory amino acid
  • Midbrain periaqueductal gray
  • Skeletal muscle vasoconstriction

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