Executive functioning in obsessive-compulsive disorder, unipolar depression, and schizophrenia

Steffen Moritz*, Christiane Birkner, Martin Kloss, Holger Jahn, Iver Hand, Christian Haasen, Michael Krausz

*Corresponding author for this work

Research output: Contribution to journalArticle

200 Citations (Scopus)

Abstract

The present study investigated whether schizophrenic, unipolar depressive, and obsessive-compulsive psychiatric patients show a distinguishable profile in tasks considered sensitive to frontal lobe functioning. Three psychiatric samples, each comprising 25 patients with little symptomatic overlap, were compared to 70 healthy controls. Participants completed several executive tasks (Wisconsin Card Sorting Test (WCST), verbal fluency, digit span, Stroop, and Trail-Making). Except for age, which was entered as a covariate, subjects did not differ in any sociodemographic background variable. Healthy controls showed superior performance relative to depressive and schizophrenic patients who exhibited comparable deficits in all tasks. Obsessive-compulsive disorder (OCD) patients revealed dysfunctions in the Trail-Making Tests A and B and in the fluency task. Dysfunctions in the domains of working memory, verbal fluency, distractibility, and concept formation were not confined to a specific psychiatric population.

Original languageEnglish
Pages (from-to)477-483
Number of pages7
JournalArchives of Clinical Neuropsychology
Volume17
Issue number5
DOIs
Publication statusPublished - 2002
Externally publishedYes

Keywords

  • Depression
  • Frontal lobe
  • Obsessive-compulsive disorder
  • Schizophrenia
  • Verbal fluency
  • Wisconsin Card Sorting Test

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