Exercise training for asbestos-related and other dust-related respiratory diseases: a randomised controlled trial

Marita Dale, Zoe M. McKeough, Phillip A Munoz, Peter Corte, Peter T. P. Bye, Jennifer A. Alison

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)
16 Downloads (Pure)

Abstract

Background: The study aimed to determine the short and long-term effects of exercise training on exercise capacity and health-related quality of life (HRQoL) compared to usual care in people with dust-related pleural and interstitial respiratory diseases. No previous studies have specifically evaluated exercise training in this patient population.

Methods: Participants with a diagnosis of a dust-related respiratory disease including asbestosis and asbestos related pleural disease were recruited and randomised to an eight-week exercise training group (EG) or a control group (CG) of usual care. Six-minute walk distance (6MWD), St George’s Respiratory Questionnaire (SGRQ) and Chronic Respiratory Disease Questionnaire (CRQ) were measured at baseline, eight weeks and 26 weeks by an assessor blinded to group allocation.

Results: Thirty-three of 35 male participants completed the study. Sixty-nine percent of participants had asbestos related pleural disease. At eight weeks, compared to the CG, the EG showed a significantly increased 6MWD (mean difference (95%CI)) 53 metres (32 to 74), improved SGRQ total score, -7 points (-13 to -1) and increased CRQ total score, 6.4 points (2.1 to 10.7). At 26 weeks significant between-group differences were maintained in 6MWD, 45 metres (17 to 73) and CRQ total score, 13.1 points (5.2 to 20.9).

Conclusion: Exercise training improved short and long-term exercise capacity and HRQoL in people with dust-related pleural and interstitial respiratory diseases.
Original languageEnglish
Article number180
Pages (from-to)1-9
Number of pages9
JournalBMC Pulmonary Medicine
Volume14
DOIs
Publication statusPublished - 18 Nov 2014
Externally publishedYes

Bibliographical note

Copyright the Author(s) 2014. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Asbestosis
  • Diffuse pleural thickening
  • Exercise
  • Health-related quality of life
  • Interstitial lung disease
  • Physical activity
  • Pulmonary rehabilitation

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