Exosomes in Alzheimer’s disease

potential role as pathological mediators, biomarkers and therapeutic targets

Sreeja Lakshmi, Musthafa Mohamed Essa, Richard E. Hartman, Gilles J. Guillemin, Sureshkumar Sivan, Preetham Elumalai*

*Corresponding author for this work

Research output: Contribution to journalReview article

Abstract

The concept of exosomes has been progressively changed from the status of cellular trashcans to multitasking organelles involved in many processes, including internalization, transport and transfer of macromolecules such as proteins, lipids and nucleic acids. While underpinning the mechanisms behind neurodegeneration and neuronal loss, exosomes were shown to be involved in carrying pathological misfolded proteins, propagation of β-amyloid protein and hyper-phosphorylated tau proteins across the brain that ultimately leads to the onset of Alzheimer’s disease (AD), the most prevailing multifactorial neurodegenerative disorder. A potential novel therapeutic role of exosomes in AD intervention is suggested by their ability to increase Aβ clearance. This review aims to highlight the important pathological mechanisms as well as therapeutic strategies involving exosomes towards AD prevention.

Original languageEnglish
Pages (from-to)2553-2559
Number of pages7
JournalNeurochemical Research
Volume45
Issue number11
Early online date25 Aug 2020
DOIs
Publication statusE-pub ahead of print - 25 Aug 2020

Keywords

  • Alzheimer´s disease
  • Biomarkers
  • Exosomes
  • Tau protein
  • β-amyloid

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