Expanded porphyrins. Synthetic materials with potential medical utility

Jonathan L. Sessler*, Nicolai A. Tvermoes, Julian Davis, Pavel Anzenbacher, Karolina Jursíková, Wataru Sato, Daniel Seidel, Vincent Lynch, Chris B. Black, Andrew Try, Bruno Andrioletti, Greg Hemmi, Tarak D. Mody, Darren J. Magda, Vladimir Král

*Corresponding author for this work

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

A number of aromatic and nonaromatic expanded porphyrins have been prepared in the authors' laboratories. These are allowing a number of important themes to be explored, including the construction of novel cation- and anion-complexing agents and the generation of drug candidates with considerable therapeutic potential. In this paper, the use of gadolinium(III) and lutetium(III) texaphyrin derivatives as, respectively, adjuvants for X-ray radiation cancer therapy and photosensitizers for use in photodynamic treatments of cancer, atheromatous plaque, and age-related macular degeneration will be reviewed. Also discussed are the use of water soluble sapphyrins as potential fluorescent phosphate sensors and organic soluble 2,3-dipyrrylquinoxaline derivatives as possible fluoride anion signaling agents. Recent synthetic work, designed to produce expanded porphyrins with new shapes and novel topologies, is also summarized.

Original languageEnglish
Pages (from-to)2009-2018
Number of pages10
JournalPure and Applied Chemistry
Volume71
Issue number11
Publication statusPublished - 1999

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