Expanding the association between the APOE gene and the risk of Alzheimer's disease: Possible roles for APOE promoter polymorphisms and alterations in APOE transcription

Simon M. Laws, Eugene Hone, Sam Gandy, Ralph N. Martins*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

170 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is the most commonly diagnosed form of dementia in the elderly. Predominantly this disease is sporadic in nature with only a small percentage of patients exhibiting a familial trait. Early-onset AD may be explained by single gene defects; however, most AD cases are late onset (> 65 years) and, although there is no known definite cause for this form of the disease, there are several known risk factors. Of these, the ε4 allele of the apolipoprotein E (apoE) gene (APOE) is a major risk factor. The ε4 allele of APOE is one of three (ε2 ε3 and ε4) common alleles generated by cysteine/arginine substitutions at two polymorphic sites. The possession of the ε4 allele is recognized as the most common identifiable genetic risk factor for late-onset AD across most populations. Unlike the pathogenic mutations in the amyloid precursor or those in the presenilins, APOE ε4 alleles increase the risk for AD but do not guarantee disease, even when present in homozygosity. In addition to the cysteine/arginine polymorphisms at the ε2/ε3/ε4 locus, polymorphisms within the proximal promoter of the APOE gene may lead to increased apoE levels by altering transcription of the APOE gene. Here we review the genetic and biochemical evidence supporting the hypothesis that regulation of apoE protein levels may contribute to the risk of AD, distinct from the well known polymorphisms at the ε2/ε3/ε4 locus.

Original languageEnglish
Pages (from-to)1215-1236
Number of pages22
JournalJournal of Neurochemistry
Volume84
Issue number6
DOIs
Publication statusPublished - Mar 2003
Externally publishedYes

Keywords

  • Alzheimers disease
  • APOE promoter
  • Apolipoprotein E

Fingerprint Dive into the research topics of 'Expanding the association between the APOE gene and the risk of Alzheimer's disease: Possible roles for APOE promoter polymorphisms and alterations in APOE transcription'. Together they form a unique fingerprint.

Cite this