Expanding the role of striatal cholinergic interneurons and the midbrain dopamine system in appetitive instrumental conditioning

Matthew J. Crossley, Jon C. Horvitz, Peter D. Balsam, F. Gregory Ashby*

*Corresponding author for this work

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The basal ganglia are a collection of subcortical nuclei thought to underlie a wide variety of vertebrate behavior. Although a great deal is known about the functional and physiological properties of the basal ganglia, relatively few models have been formally developed that have been tested against both behavioral and physiological data. Our previous work (Ashby FG, Crossley MJ. J Cogn Neurosci 23: 1549 –1566, 2011) showed that a model grounded in the neurobiology of the basal ganglia could account for basic single-neuron recording data, as well as behavioral phenomena such as fast reacquisition that constrain models of conditioning. In this article we show that this same model accounts for a variety of appetitive instrumental conditioning phenomena, including the partial reinforcement extinction (PRE) effect, rapid and slowed reacquisition following extinction, and renewal of previously extinguished instrumental responses by environmental context cues.

Original languageEnglish
Pages (from-to)240-254
Number of pages15
JournalJournal of Neurophysiology
Volume115
Issue number1
DOIs
Publication statusPublished - Jan 2016
Externally publishedYes

Fingerprint Dive into the research topics of 'Expanding the role of striatal cholinergic interneurons and the midbrain dopamine system in appetitive instrumental conditioning'. Together they form a unique fingerprint.

  • Cite this