Experimental animal models of arteriovenous malformation: a review

Jude Amal Raj, Marcus Stoodley*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

5 Citations (Scopus)
4 Downloads (Pure)

Abstract

Arteriovenous malformations (AVMs) are congenital lesions that cause brain haemorrhage in children and young adults. Current treatment modalities include surgery, radiosurgery and embolization. These treatments are generally effective only for small AVMs. Over one third of AVMs cannot be treated safely and effectively with existing options. Several animal models have been developed with the aims of understanding AVM pathophysiology and improving treatment. No animal model perfectly mimics a human AVM. Each model has limitations and advantages. Models contribute to the understanding of AVMs and hopefully to the development of improved therapies. This paper reviews animal models of AVMs and their advantages and disadvantages.

Original languageEnglish
Pages (from-to)97-110
Number of pages14
JournalVeterinary Sciences
Volume2
Issue number2
DOIs
Publication statusPublished - 19 Jun 2015

Bibliographical note

Copyright the Author(s) 2015. Version archived for private and non-commercial use with the permission of the author/s and according to publisher conditions. For further rights please contact the publisher.

Keywords

  • Animal models
  • Cerebral arteriovenous malformations

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